Glioblastoma (GBM) is one of the most aggressive malignant tumors of the brain. We queried PubMed for articles about molecular predictor markers in GBM. This scoping review aims to analyze the most important outcome predictors in patients with GBM and to compare these factors in terms of absolute months of survival benefit and percentages. Performing a gross total resection for patients with GBM undergoing optimal chemo- and radiotherapy provides a significant benefit in overall survival compared to those patients who received a subtotal or partial resection. However, compared to IDH-Wildtype GBMs, patients with IDH-Mutant 1/2 GBMs have an increased survival. MGMT promoter methylation status is another strong outcome predictor for patients with GBM. In the reviewed literature, patients with methylated MGMT promoter lived approximately 50% to 90% longer than those with an unmethylated MGMT gene promoter. Moreover, KPS is an important predictor of survival and quality of life, demonstrating that we should refrain from aggressive surgery in important brain areas. As new therapies (such as TTFs) emerge, we are optimistic that the overall median survival will increase, even for IDH-Wildtype GBMs. In conclusion, molecular profiles are stronger outcome predictors than the extent of neurosurgical resection for GBM.
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Nankai Univ, Sch Med, Tianjin, Peoples R China
Chinese Peoples Liberat Army Gen Hosp, Med Ctr 1, Dept Neurosurg, Beijing, Peoples R ChinaNankai Univ, Sch Med, Tianjin, Peoples R China
Hu, Wentao
Liu, Hongyu
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Chinese Peoples Liberat Army Gen Hosp, Med Ctr 1, Dept Neurosurg, Beijing, Peoples R ChinaNankai Univ, Sch Med, Tianjin, Peoples R China
Liu, Hongyu
Li, Ze
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Chinese Peoples Liberat Army Gen Hosp, Med Ctr 1, Dept Neurosurg, Beijing, Peoples R ChinaNankai Univ, Sch Med, Tianjin, Peoples R China
Li, Ze
Liu, Jialin
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Chinese Peoples Liberat Army Gen Hosp, Med Ctr 1, Dept Neurosurg, Beijing, Peoples R ChinaNankai Univ, Sch Med, Tianjin, Peoples R China
Liu, Jialin
Chen, Ling
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Chinese Peoples Liberat Army Gen Hosp, Med Ctr 1, Dept Neurosurg, Beijing, Peoples R ChinaNankai Univ, Sch Med, Tianjin, Peoples R China
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Yonsei Univ, Coll Med, Dept Neurosurg, Res Inst Radiol Sci,Ctr Clin Imaging Data Sci, Seoul, South KoreaYonsei Univ, Dept Radiol, Coll Med, Yongin, Gyeonggi Do, South Korea
Chang, J. H.
Kim, S. H.
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Yonsei Univ, Coll Med, Dept Pathol, Seoul, South KoreaYonsei Univ, Dept Radiol, Coll Med, Yongin, Gyeonggi Do, South Korea
Kim, S. H.
Cha, S.
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Univ Calif San Francisco, Dept Radiol & Biomed Imaging, San Francisco, CA 94143 USAYonsei Univ, Dept Radiol, Coll Med, Yongin, Gyeonggi Do, South Korea
Cha, S.
Lee, S-K
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Yonsei Univ, Coll Med, Dept Radiol, Seoul, South KoreaYonsei Univ, Dept Radiol, Coll Med, Yongin, Gyeonggi Do, South Korea
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Univ Texas Austin, Dell Med Sch, Dept Surg & Perioperat Care, Austin, TX 78712 USAUniv Texas Austin, Dell Med Sch, Dept Surg & Perioperat Care, Austin, TX 78712 USA
Jayakumar, Prakash
Lin, Eugenia
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Univ Texas Austin, Dell Med Sch, Dept Surg & Perioperat Care, Austin, TX 78712 USAUniv Texas Austin, Dell Med Sch, Dept Surg & Perioperat Care, Austin, TX 78712 USA
Lin, Eugenia
Galea, Vincent
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New York Med Coll, Sch Med, Valhalla, NY 10595 USAUniv Texas Austin, Dell Med Sch, Dept Surg & Perioperat Care, Austin, TX 78712 USA
Galea, Vincent
Mathew, Abraham J.
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Univ Texas Austin, Dell Med Sch, Dept Surg & Perioperat Care, Austin, TX 78712 USAUniv Texas Austin, Dell Med Sch, Dept Surg & Perioperat Care, Austin, TX 78712 USA
Mathew, Abraham J.
Panda, Nikhil
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Harvard Med Sch, Massachusetts Gen Hosp, Dept Surg, Boston, MA 02114 USAUniv Texas Austin, Dell Med Sch, Dept Surg & Perioperat Care, Austin, TX 78712 USA
Panda, Nikhil
Vetter, Imelda
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Univ Texas Austin, Dell Med Sch, Dept Med Educ, Austin, TX 78712 USAUniv Texas Austin, Dell Med Sch, Dept Surg & Perioperat Care, Austin, TX 78712 USA
Vetter, Imelda
Haynes, Alex B.
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Univ Texas Austin, Dell Med Sch, Dept Surg & Perioperat Care, Austin, TX 78712 USAUniv Texas Austin, Dell Med Sch, Dept Surg & Perioperat Care, Austin, TX 78712 USA
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Inst Cancerol Strasbourg Europe, ICANS, Dept Radiotherapy, 17 Rue Albert Calmette, F-67200 Strasbourg, FranceInst Cancerol Strasbourg Europe, ICANS, Dept Radiotherapy, 17 Rue Albert Calmette, F-67200 Strasbourg, France
Le Fevre, Clara
Lhermitte, Benoit
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机构:
Hautepierre Univ Hosp, Dept Pathol, 1 Ave Moliere, F-67200 Strasbourg, FranceInst Cancerol Strasbourg Europe, ICANS, Dept Radiotherapy, 17 Rue Albert Calmette, F-67200 Strasbourg, France
Lhermitte, Benoit
Ahle, Guido
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Hop Civils Colmar, Dept Neurol, 39 Ave Liberte, F-68024 Colmar, FranceInst Cancerol Strasbourg Europe, ICANS, Dept Radiotherapy, 17 Rue Albert Calmette, F-67200 Strasbourg, France
Ahle, Guido
Chambrelant, Isabelle
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机构:
Inst Cancerol Strasbourg Europe, ICANS, Dept Radiotherapy, 17 Rue Albert Calmette, F-67200 Strasbourg, FranceInst Cancerol Strasbourg Europe, ICANS, Dept Radiotherapy, 17 Rue Albert Calmette, F-67200 Strasbourg, France
Chambrelant, Isabelle
Cebula, Helene
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机构:
Hautepierre Univ Hosp, Dept Neurosurg, 1 Ave Moliere, F-67200 Strasbourg, FranceInst Cancerol Strasbourg Europe, ICANS, Dept Radiotherapy, 17 Rue Albert Calmette, F-67200 Strasbourg, France
Cebula, Helene
Antoni, Delphine
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机构:
Inst Cancerol Strasbourg Europe, ICANS, Dept Radiotherapy, 17 Rue Albert Calmette, F-67200 Strasbourg, FranceInst Cancerol Strasbourg Europe, ICANS, Dept Radiotherapy, 17 Rue Albert Calmette, F-67200 Strasbourg, France
Antoni, Delphine
Keller, Audrey
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机构:
Inst Cancerol Strasbourg Europe, ICANS, Dept Radiotherapy, 17 Rue Albert Calmette, F-67200 Strasbourg, FranceInst Cancerol Strasbourg Europe, ICANS, Dept Radiotherapy, 17 Rue Albert Calmette, F-67200 Strasbourg, France
Keller, Audrey
Schott, Roland
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机构:
Inst Cancerol Strasbourg Europe, ICANS, Dept Med Oncol, 17 Rue Albert Calmette, F-67200 Strasbourg, FranceInst Cancerol Strasbourg Europe, ICANS, Dept Radiotherapy, 17 Rue Albert Calmette, F-67200 Strasbourg, France
Schott, Roland
Thiery, Alicia
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Inst Cancerol Strasbourg Europe, ICANS, Dept Publ Hlth, 17 Rue Albert Calmette, F-67200 Strasbourg, FranceInst Cancerol Strasbourg Europe, ICANS, Dept Radiotherapy, 17 Rue Albert Calmette, F-67200 Strasbourg, France
Thiery, Alicia
Constans, Jean-Marc
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Amiens Picardie Univ Hosp, Dept Radiol, 1 Rond Point Prof Christian Cabrol, F-80054 Amiens 1, FranceInst Cancerol Strasbourg Europe, ICANS, Dept Radiotherapy, 17 Rue Albert Calmette, F-67200 Strasbourg, France
Constans, Jean-Marc
Noel, Georges
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机构:
Inst Cancerol Strasbourg Europe, ICANS, Dept Radiotherapy, 17 Rue Albert Calmette, F-67200 Strasbourg, FranceInst Cancerol Strasbourg Europe, ICANS, Dept Radiotherapy, 17 Rue Albert Calmette, F-67200 Strasbourg, France