Molecular Profile as an Outcome Predictor in Glioblastoma along with MRI Features and Surgical Resection: A Scoping Review

被引:4
|
作者
Papacocea, Serban Iancu [1 ]
Vrinceanu, Daniela [2 ]
Dumitru, Mihai [2 ]
Manole, Felicia [3 ]
Serboiu, Crenguta [4 ]
Papacocea, Marius Toma [1 ]
机构
[1] Carol Davila Univ Med & Pharm, Neurosurg Dept, Bucharest 020021, Romania
[2] Carol Davila Univ Med & Pharm, ENT Dept, Bucharest 020021, Romania
[3] Univ Oradea, Fac Med, ENT Dept, Oradea 410073, Romania
[4] Carol Davila Univ Med & Pharm, Cellular Biol & Histol Dept, Bucharest 020021, Romania
关键词
GBM; molecular; predictor; outcome; surgery; MGMT PROMOTER METHYLATION; CENTRAL-NERVOUS-SYSTEM; GROWTH-FACTOR RECEPTOR; TERT PROMOTER; PROGNOSTIC VALUE; MALIGNANT GLIOMA; IDH1; MUTATIONS; PHASE-II; TEMOZOLOMIDE; SURVIVAL;
D O I
10.3390/ijms25179714
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Glioblastoma (GBM) is one of the most aggressive malignant tumors of the brain. We queried PubMed for articles about molecular predictor markers in GBM. This scoping review aims to analyze the most important outcome predictors in patients with GBM and to compare these factors in terms of absolute months of survival benefit and percentages. Performing a gross total resection for patients with GBM undergoing optimal chemo- and radiotherapy provides a significant benefit in overall survival compared to those patients who received a subtotal or partial resection. However, compared to IDH-Wildtype GBMs, patients with IDH-Mutant 1/2 GBMs have an increased survival. MGMT promoter methylation status is another strong outcome predictor for patients with GBM. In the reviewed literature, patients with methylated MGMT promoter lived approximately 50% to 90% longer than those with an unmethylated MGMT gene promoter. Moreover, KPS is an important predictor of survival and quality of life, demonstrating that we should refrain from aggressive surgery in important brain areas. As new therapies (such as TTFs) emerge, we are optimistic that the overall median survival will increase, even for IDH-Wildtype GBMs. In conclusion, molecular profiles are stronger outcome predictors than the extent of neurosurgical resection for GBM.
引用
收藏
页数:19
相关论文
共 46 条
  • [1] Molecular profile of long-term survivors of glioblastoma: A scoping review of the literature
    Gately, L.
    McLachlan, S. A.
    Philip, J.
    Rathi, V.
    Dowling, A.
    JOURNAL OF CLINICAL NEUROSCIENCE, 2019, 68 : 1 - 8
  • [2] Is surgical resection useful in elderly newly diagnosed glioblastoma patients? Outcome evaluation and prognostic factors assessment
    Pessina, Federico
    Navarria, Pierina
    Cozzi, Luca
    Ruda, Roberta
    Nibali, Marco Conti
    Simonelli, Matteo
    Costa, Francesco
    Santoro, Armando
    Clerici, Elena
    Carta, Giulio
    Scorsetti, Marta
    Bello, Lorenzo
    ACTA NEUROCHIRURGICA, 2018, 160 (09) : 1779 - 1787
  • [3] Intramedullary cavernous haemangiomas: clinical features, imaging diagnosis, surgical resection and outcome
    Tu, YK
    Liu, HM
    Chen, SJ
    Lin, SM
    JOURNAL OF CLINICAL NEUROSCIENCE, 1999, 6 (03) : 212 - 216
  • [4] Surgical outcome and molecular pattern characterization of recurrent glioblastoma multiforme: A single-center retrospective series
    Montemurro, Nicola
    Fanelli, Giuseppe Nicolo
    Scatena, Cristian
    Ortenzi, Valerio
    Pasqualetti, Francesco
    Mazzanti, Chiara Maria
    Morganti, Riccardo
    Paiar, Fabiola
    Naccarato, Antonio Giuseppe
    Perrini, Paolo
    CLINICAL NEUROLOGY AND NEUROSURGERY, 2021, 207
  • [5] Fetal lung MRI and features predicting post- natal outcome: a scoping review of the current literature
    Whitby, Elspeth
    Gaunt, Trevor
    BRITISH JOURNAL OF RADIOLOGY, 2023, 96 (1147):
  • [6] Prognostic factors affecting outcome of multifocal or multicentric glioblastoma: A scoping review
    Das, Saikat
    Mishra, Rakesh Kumar
    Agrawal, Amit
    JOURNAL OF NEUROSCIENCES IN RURAL PRACTICE, 2023, 14 (02) : 199 - 209
  • [7] Glioblastoma: Molecular profile and immunophenotypic analysis as prognostic tools for tailored therapy and decision making in a recent surgical series
    Salvati, Maurizio
    Tariciotti, Leonardo
    Brunetto, Giacoma M. F.
    Gallo, Gaetano
    Santoro, Francesca
    Frati, Alessandro
    Santoro, Antonio
    INTERDISCIPLINARY NEUROSURGERY-ADVANCED TECHNIQUES AND CASE MANAGEMENT, 2020, 20
  • [8] Established and emerging variants of glioblastoma multiforme: review of morphological and molecular features
    Karsy, Michael
    Gelbman, Marshall
    Shah, Paarth
    Balumbu, Odessa
    Moy, Fred
    Arslan, Erol
    FOLIA NEUROPATHOLOGICA, 2012, 50 (04) : 301 - 321
  • [9] Potential of pre-operative MRI features in glioblastoma to predict for molecular stem cell subtype and patient overall survival
    Eckert, Franziska
    Ganser, Katrin
    Bender, Benjamin
    Schittenhelm, Jens
    Skardelly, Marco
    Behling, Felix
    Tabatabai, Ghazaleh
    Hoffmann, Elgin
    Zips, Daniel
    Huber, Stephan M.
    Paulsen, Frank
    RADIOTHERAPY AND ONCOLOGY, 2023, 188
  • [10] Identification of glioblastoma molecular subtype and prognosis based on deep MRI features
    Su, Ran
    Liu, Xiaoying
    Jin, Qiangguo
    Liu, Xiaofeng
    Wei, Leyi
    KNOWLEDGE-BASED SYSTEMS, 2021, 232