The Enigmatic Interplay of Interleukin-10 in the Synergy of HIV Infection Comorbid with Preeclampsia

被引:0
|
作者
Naidoo, Shirelle Janine [1 ]
Naicker, Thajasvarie [1 ]
机构
[1] Univ KwaZulu Natal, Nelson R Mandela Sch Med, Dept Opt & Imaging, ZA-4001 Durban, South Africa
关键词
interleukin-10; preeclampsia; human immunodeficiency virus; GENE POLYMORPHISMS; PROMOTER POLYMORPHISMS; PREGNANT-WOMEN; IFN-GAMMA; ASSOCIATION; IL-10; RISK; SUSCEPTIBILITY; IMPLANTATION; PROGRESSION;
D O I
10.3390/ijms25179434
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cytokines coordinate the intricate choreography of the immune system, directing cellular activities that mediate inflammation, pathogen defense, pathology and tissue repair. Within this spectrum, the anti-inflammatory prowess of interleukin-10 (IL-10) predominates in immune homeostasis. In normal pregnancy, the dynamic shift of IL-10 across trimesters maintains maternal immune tolerance ensuring fetal development and pregnancy success. Unravelling the dysregulation of IL-10 in pregnancy complications is vital, particularly in the heightened inflammatory condition of preeclampsia. Of note, a reduction in IL-10 levels contributes to endothelial dysfunction. In human immunodeficiency virus (HIV) infection, a complex interplay of IL-10 occurs, displaying a paradoxical paradigm of being immune-protective yet aiding viral persistence. Genetic variations in the IL-10 gene further modulate susceptibility to HIV infection and preeclampsia, albeit with nuanced effects across populations. This review outlines the conceptual framework underlying the role of IL-10 in the duality of normal pregnancy and preeclampsia together with HIV infection, thus highlighting its regulatory mechanisms and genetic influences. Synthesizing these findings in immune modulation presents avenues for therapeutic interventions in pregnancy complications comorbid with HIV infection.
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页数:14
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