The Enigmatic Interplay of Interleukin-10 in the Synergy of HIV Infection Comorbid with Preeclampsia

被引:0
|
作者
Naidoo, Shirelle Janine [1 ]
Naicker, Thajasvarie [1 ]
机构
[1] Univ KwaZulu Natal, Nelson R Mandela Sch Med, Dept Opt & Imaging, ZA-4001 Durban, South Africa
关键词
interleukin-10; preeclampsia; human immunodeficiency virus; GENE POLYMORPHISMS; PROMOTER POLYMORPHISMS; PREGNANT-WOMEN; IFN-GAMMA; ASSOCIATION; IL-10; RISK; SUSCEPTIBILITY; IMPLANTATION; PROGRESSION;
D O I
10.3390/ijms25179434
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cytokines coordinate the intricate choreography of the immune system, directing cellular activities that mediate inflammation, pathogen defense, pathology and tissue repair. Within this spectrum, the anti-inflammatory prowess of interleukin-10 (IL-10) predominates in immune homeostasis. In normal pregnancy, the dynamic shift of IL-10 across trimesters maintains maternal immune tolerance ensuring fetal development and pregnancy success. Unravelling the dysregulation of IL-10 in pregnancy complications is vital, particularly in the heightened inflammatory condition of preeclampsia. Of note, a reduction in IL-10 levels contributes to endothelial dysfunction. In human immunodeficiency virus (HIV) infection, a complex interplay of IL-10 occurs, displaying a paradoxical paradigm of being immune-protective yet aiding viral persistence. Genetic variations in the IL-10 gene further modulate susceptibility to HIV infection and preeclampsia, albeit with nuanced effects across populations. This review outlines the conceptual framework underlying the role of IL-10 in the duality of normal pregnancy and preeclampsia together with HIV infection, thus highlighting its regulatory mechanisms and genetic influences. Synthesizing these findings in immune modulation presents avenues for therapeutic interventions in pregnancy complications comorbid with HIV infection.
引用
收藏
页数:14
相关论文
共 50 条
  • [21] A meta-analysis of tumor necrosis factor-alpha, interleukin-6, and interleukin-10 in preeclampsia
    Xie, Cui
    Yao, Mian Zhi
    Liu, Jiang Bo
    Xiong, Li Kuan
    CYTOKINE, 2011, 56 (03) : 550 - 559
  • [22] Tumor Necrosis Factor-Alpha, Interleukin-6, and Interleukin-10 Levels are Altered in Preeclampsia: A Systematic Review and Meta-Analysis
    Lau, Sien Yee
    Guild, Sarah-Jane
    Barrett, Carolyn J.
    Chen, Qi
    McCowan, Leslie
    Jordan, Vanessa
    Chamley, Lawrence W.
    AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2013, 70 (05) : 412 - 427
  • [23] Placental deficiency of interleukin-10 (IL-10) in preeclampsia and its relationship to an IL10 promoter polymorphism
    Makris, A
    Xu, B
    Yu, B
    Thornton, C
    Hennessy, A
    PLACENTA, 2006, 27 (4-5) : 445 - 451
  • [24] Interleukin-10 gene polymorphism in chronic hepatitis B virus infection
    Artan, R.
    Gokdemir, O.
    Sarigul, M.
    Dikici, B.
    Gulkesen, H.
    Yilmaz, A.
    ACTA PAEDIATRICA, 2008, 97 : 129 - 129
  • [25] Cytomegalovirus infection is associated with elevated interleukin-10 in coronary artery disease
    Sun, YH
    Pei, WD
    Welte, T
    Wu, YJ
    Ye, SD
    Yang, YJ
    ATHEROSCLEROSIS, 2005, 179 (01) : 133 - 137
  • [26] Synthesis of Interleukin-10 in Patients with Ulcerative Colitis and Helicobacter pylori Infection
    Yamamoto-Furusho, Jesus K.
    Fonseca-Camarillo, Gabriela
    Barrera-Ochoa, Carlos A.
    Furuzawa-Carballeda, Janette
    GASTROENTEROLOGY RESEARCH AND PRACTICE, 2020, 2020
  • [27] Berberine alleviates preeclampsia possibly by regulating the expression of interleukin-2/interleukin-10 and Bcl-2/Bax
    Wang, Ailan
    Liu, Qingcui
    Zhang, Jin
    Zheng, Rui
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2015, 8 (09): : 16301 - 16307
  • [28] Is the central complement component C3 altered in the synergy of HIV infection and preeclampsia?
    David, Mikyle
    Singh, Shoohana
    Naicker, Thajasvarie
    EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY-X, 2023, 20
  • [29] Association of interleukin-10 polymorphisms with chronic hepatitis C virus infection in a case-control study and its effect on the response to combined pegylated interferon/ribavirin therapy
    Khan, A. J.
    Saraswat, V. A.
    Choudhuri, G.
    Parmar, D.
    Negi, T. S.
    Mohindra, S.
    EPIDEMIOLOGY AND INFECTION, 2015, 143 (01) : 71 - 80
  • [30] Preeclamptic Women Have Decreased Circulating IL-10 (Interleukin-10) Values at the Time of Preeclampsia Diagnosis Systematic Review and Meta-Analysis
    Nath, Meryl C.
    Cubro, Hajrunisa
    McCormick, Daniel J.
    Milic, Natasa M.
    Garovic, Vesna D.
    HYPERTENSION, 2020, 76 (06) : 1817 - 1827