Multi-Drug Resistance and Breast Cancer Progression via Toll-Like Receptors (TLRs) Signaling

被引：2

作者：

Pallathadka, Harikumar ^{[1
]}

Khaleel, Abdulrahman Qais ^{[2
]}

Zwamel, Ahmed Hussein ^{[3
,4
,5
]}

Malathi, H. ^{[6
]}

Sharma, Snehlata ^{[7
]}

Rizaev, Jasur Alimdjanovich ^{[8
]}

Mustafa, Yasser Fakri ^{[9
]}

Pramanik, Atreyi ^{[10
]}

Alubiady, Mahmood Hasen Shuhata ^{[11
]}

Jawad, Mohammed Abed ^{[12
]}

机构：

[1] Manipur Int Univ, Imphal, Manipur, India

[2] Al Maarif Univ Coll, Dept Med Instruments Engn, Al Anbar 31001, Iraq

[3] Islamic Univ, Med Lab Tech Coll, Najaf, Iraq

[4] Islamic Univ Al Diwaniyah, Med Lab Tech Coll, Al Diwaniyah, Iraq

[5] Islamic Univ Babylon, Med Lab Tech Coll, Babylon, Iraq

[6] JAIN Deemed Univ, Sch Sci, Dept Biotechnol & Genet, Bangalore, Karnataka, India

[7] Chandigarh Pharm Coll, Chandigarh Grp Coll, Mohali 140307, Punjab, India

[8] Samarkand State Med Univ, Dept Publ Hlth & Healthcare Management, 18 Amir Temur St, Samarkand, Uzbekistan

[9] Univ Mosul, Coll Pharm, Dept Pharmaceut Chem, Mosul 41001, Iraq

[10] Uttaranchal Univ, Sch Appl & Life Sci, Div Res & Innovat, Dehra Dun 248007, Uttarakhand, India

[11] Al Hadi Univ Coll, Mahmood Hasen Shuhata alubiady, Baghdad 10011, Iraq

[12] AL Nisour Univ Coll, Dept Med Labs Technol, Baghdad, Iraq

来源：

CELL BIOCHEMISTRY AND BIOPHYSICS | 2024年 / 82卷 / 04期

关键词：

Toll-like receptors (TLRs); Breast cancer; Pathogenesis; Drug resistance; Progression; NF-KAPPA-B; T-CELL; INNATE IMMUNITY; 9; EXPRESSION; INFLAMMATION; MECHANISMS; INVASION; PATHWAY; DAMPS; PROLIFERATION;

D O I：

10.1007/s12013-024-01418-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Toll-like receptors (TLRs) are essential receptors involved in inflammation and innate immunity. Various types of cancer cells, as well as innate immune cells, express TLRs. There is mounting proof that TLRs are critical to the development and spread of cancer as well as metabolism. In breast cancer, up-regulated levels of TLRs have been linked to the aggressiveness of the diseases, worse treatment outcomes, and the emergence of therapeutic resistance. Patients with advanced non-resectable, recurring, and metastatic breast cancer currently have few available treatment choices. An intriguing new strategy is an innate immunity-mediated anticancer immunotherapy, either used alone or in conjunction with existing treatments. In fact, several TLR agonists and antagonists have been used in clinical studies for anti-cancer immunotherapy. Consequently, TLRs serve as critical targets for controlling the course of breast cancer and treatment resistance in addition to being implicated in immune responses against pathogen infection and cancer immunology. In this review, we deliver an overview of the most current findings on TLR involvement in the development of breast cancer and treatment resistance.

引用

页码：3015 / 3030

页数：16

共 155 条

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