Long term effect of fluoxetine and memantine on biochemical markers of Alzheimer's disease in scopolamine-induced mice

被引：0
作者：
Istifo, N. N. H. [1 ]
Al-Zobaidy, M. A. J. [2 ,3 ]
Abass, K. S. [1 ]
机构：
[1] Univ Kirkuk, Al Sayada Area, At Tamim 36013, Iraq
[2] Univ Baghdad, Baghdad, Iraq
[3] Baghdad Univ, Baghdad 10071, Iraq
来源：
REGULATORY MECHANISMS IN BIOSYSTEMS | 2024年 / 15卷 / 02期
关键词：
amyloid (3; antioxidant; brain derived neurotrophic factor; neuronal plasticity; oxidative stress; TRANSGENIC MOUSE MODEL; HIPPOCAMPAL; EXPRESSION; MEMORY;
D O I：
10.15421/022433
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Alzheimer's disease is a chronic neurological illness that causes considerable cognitive impairment. However, there is no effective treatment for this disease. Therefore, the current study aimed at investigating the long-term effects of fluoxetine and memantine on biochemical markers of Alzheimer's disease in scopolamine-induced mice. In this study, adult female mice were divided into four equal groups; normal control received distilled water only, the untreated Alzheimer's disease group received scopolamine intraperitoneal IP/SCM for 14 days, following which distilled water was given for six months, the memantine-treated Alzheimer's disease group received IP/SCM for 14 days then memantine hydrochloride for 6 months, the fluoxetine-treated Alzheimer's disease group received IP/SCM for 14 days then fluoxetine hydrochloride for 6 months. The results show that after 2 weeks of induction the mean level of amyloid (3 and MDA were significantly elevated, while the mean level of BDNF and TAS were significantly reduced in comparison with the normal control group. After 3 months, both treatments (memantine and fluoxetine) caused a highly significant decrease in the mean levels of amyloid (3 and malondialdehyde as well as an increase in the mean levels of brain derived neurotrophic factor and total antioxidant status in Alzheimer's disease treated mice in comparison with Alzheimer's disease untreated mice. However, after 6 months of treatment, the effects of fluoxetine were more significant than those of memantine. In conclusion, fluoxetine has significant effects on biochemical markers of Alzheimer's disease and these effects are time-dependent as well as more significant than those of memantine, which suggests the potential usefulness of the former in treatment of this disease.
引用
收藏
页码：226 / 229
页数：4
相关论文
共 38 条
[1]   Antidepressants are a rational complementary therapy for the treatment of Alzheimer's disease [J].
Aboukhatwa, Marwa ;
Dosanjh, Laura ;
Luo, Yuan .
MOLECULAR NEURODEGENERATION, 2010, 5
[2]   Fluoxetine ameliorates Alzheimer's disease progression and prevents the exacerbation of cardiovascular dysfunction of socially isolated depressed rats through activation of Nrf2/HO-1 and hindering TLR4/NLRP3 inflammasome signaling pathway [J].
Abu-Elfotuh, Karema ;
Al-Najjar, Aya H. ;
Mohammed, Asmaa A. ;
Aboutaleb, Amany S. ;
Badawi, Ghada A. .
INTERNATIONAL IMMUNOPHARMACOLOGY, 2022, 104
[3]   Attenuative Effects of Fluoxetine and Triticum aestivum against Aluminum-Induced Alzheimer's Disease in Rats: The Possible Consequences on Hepatotoxicity and Nephrotoxicity [J].
Abu-Elfotuh, Karema ;
Ragab, Ghada M. ;
Salahuddin, Ahmad ;
Jamil, Lubna ;
Haleem, Ekram Nemr Abd Al .
MOLECULES, 2021, 26 (21)
[4]   Memantine and its role in parkinsonism, seizure, depression, migraine headache, and Alzheimer's disease [J].
Al-hussaniy, Hany Akeel ;
Alkhafaje, Zahraa ;
Altamimi, Zahraa S. ;
Oraibi, Amjad I. ;
Abdalhassan, Aboalhassan Hayder ;
Abdulhamza, Hayder M. ;
AL-Zobaidy, Mohammed J. .
PHARMACIA, 2023, 70 (02) :291-297
[5]   Neuroprotective Effect of Nanodiamond in Alzheimer's Disease Rat Model: a Pivotal Role for Modulating NF-κB and STAT3 Signaling [J].
Alawdi, Shawqi H. ;
El-Denshary, Ezzeldin S. ;
Safar, Marwa M. ;
Eidi, Housam ;
David, Marie-Odile ;
Abdel-Wahhab, Mosaad A. .
MOLECULAR NEUROBIOLOGY, 2017, 54 (03) :1906-1918
[6]   Ameliorative effect of vanillin on scopolamine-induced dementia-like cognitive impairment in a mouse model [J].
Anand, Abhinav ;
Khurana, Navneet ;
Ali, Nemat ;
AlAsmari, Abdullah F. F. ;
Alharbi, Metab ;
Waseem, Mohammad ;
Sharma, Neha .
FRONTIERS IN NEUROSCIENCE, 2022, 16
[7]   Clavulanic Acid: A Novel Potential Agent in Prevention and Treatment of Scopolamine-Induced Alzheimer's Disease [J].
Anoush, Mahdieh ;
Pourmansouri, Zeinab ;
Javadi, Rafi ;
GhorbanPour, Benyamin ;
Shara, Ali ;
Mohamadpour, Hamed ;
Anarkooli, Iraj jafari ;
Andalib, Sina .
ACS OMEGA, 2022, 7 (16) :13861-13869
[8]   Evaluation of the protective effect of Myrtus communis in scopolamine induced Alzheimer model through cholinergic receptors [J].
Aykac, Asli ;
Ozbeyli, Dilek ;
Uncu, Murat ;
Ertas, Busra ;
Kilinc, Olca ;
Sen, Ali ;
Orun, Oya ;
Sener, Goksel .
GENE, 2019, 689 :194-201
[9]   Effect of Glycyrrhizic Acid on Scopolamine-Induced Cognitive Impairment in Mice [J].
Ban, Ju Yeon ;
Park, Hyun Kyung ;
Kim, Su Kang .
INTERNATIONAL NEUROUROLOGY JOURNAL, 2020, 24 :S48-S55
[10]   Activation of Extrasynaptic, But Not Synaptic, NMDA Receptors Modifies Amyloid Precursor Protein Expression Pattern and Increases Amyloid-β Production [J].
Bordji, Karim ;
Becerril-Ortega, Javier ;
Nicole, Olivier ;
Buisson, Alain .
JOURNAL OF NEUROSCIENCE, 2010, 30 (47) :15927-15942
1234