Tongxinluo capsule as a multi-functional traditional Chinese medicine in treating cardiovascular disease: A review of components, pharmacological mechanisms, and clinical applications

被引：2
作者：
Xin, Jingjing [1 ,2 ,3 ]
Wang, Tongxing [2 ,3 ]
Hou, Bin [2 ,3 ]
Lu, Xuan [1 ,2 ,3 ]
Han, Ningxin [1 ,2 ,3 ]
He, Yanling [2 ,3 ,4 ]
Zhang, Dan [2 ,3 ]
Wang, Xiaoqi [2 ,3 ]
Wei, Cong [2 ,3 ]
Jia, Zhenhua [1 ,2 ,3 ,5 ]
机构：
[1] Hebei Med Univ, Grad Sch, Shijiazhuang 050017, Peoples R China
[2] State Key Lab Innovat & Transformat Luobing Theory, Shijiazhuang 050035, Peoples R China
[3] Key Lab State Adm TCM Cardiocerebral Vessel Collat, Shijiazhuang 050035, Peoples R China
[4] Hebei Univ Chinese Med, Grad Sch, Shijiazhuang 050090, Hebei, Peoples R China
[5] Hebei Med Univ, Affiliated Yiling Hosp, High Level TCM Key Disciplines Natl Adm Tradit Chi, Key Disciplines State Adm TCM Collateral Dis, Shijiazhuang 050091, Hebei, Peoples R China
来源：
HELIYON | 2024年 / 10卷 / 13期
基金：
中国国家自然科学基金;
关键词：
Tongxinluo capsules; Cardiovascular disease; Mechanism of action; Network pharmacology; Clinical application; MICROVASCULAR ENDOTHELIAL-CELLS; ISCHEMIA-REPERFUSION INJURY; ACUTE MYOCARDIAL-INFARCTION; MESENCHYMAL STEM-CELLS; LOW-DENSITY-LIPOPROTEIN; OXIDATIVE STRESS; DOUBLE-BLIND; PLATELET-AGGREGATION; NEOINTIMA FORMATION; GINSENOSIDE RB1;
D O I：
10.1016/j.heliyon.2024.e33309
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Cardiovascular diseases (CVDs) are one of the most significant diseases that pose a threat to human health. The innovative traditional Chinese medicine Tongxinluo Capsule, developed under the guidance of the theory of traditional Chinese medicine, has good clinical efficacy in various cardiovascular diseases, this medicine has effects such as blood protection, vascular protection, myocardial protection, stabilizing vulnerable plaques, and vasodilation. However, CVDs are a multifactorial disease, and their underlying mechanisms are not fully understood. Therefore, exploring the mechanism of action and clinical application of Tongxinluo Capsule in the treatment of various cardiovascular diseases is beneficial for exerting its therapeutic effect from multiple components, targets, and pathways. At the same time, it provides broader treatment ideas for other difficult to treat diseases in the cardiovascular event chain, and has significant theoretical and clinical significance for improving the treatment of cardiovascular diseases with traditional Chinese medicine.
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页数：27
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