Engineering multifunctional GRP78-CAR CIK cells to target relapsed/refractory pediatric AML

被引:0
|
作者
Hopke, E. [1 ]
Bhayadia, R. [1 ]
Moser, L. [1 ]
Prufer, M. [2 ]
Laszig, S. [1 ]
Soldierer, M. [3 ]
Issa, H. [1 ]
Wels, W. S. [2 ]
Klusmann, J. H. [1 ]
Rettinger, E. [1 ]
机构
[1] Goethe Univ Frankfurt, Univ Hosp, Dept Children & Adolescents, Frankfurt, Germany
[2] Inst Tumor Biol & Expt Therapy, Georg Speyer Haus, Frankfurt, Germany
[3] Univ Duisburg Essen, Univ Childrens Hosp Essen, Dept Pediat 3, Essen, Germany
来源
KLINISCHE PADIATRIE | 2024年 / 236卷 / 03期
关键词
D O I
10.1055/s-0044-1786591
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
0040
引用
收藏
页码:208 / 208
页数:1
相关论文
共 27 条
  • [21] Auto Hematopoietic Stem Cell Transplantation Combined with Another Target Humanized CART Cells for Refractory/Relapsed B-Cell NonHodgkin Lymphoma after Failure of Murinized CD19-CAR-T Therapy
    Hu, Kai
    Yang, Fan
    Liu, Rui
    Xu, Teng
    Zheng, Peihao
    Feng, Shaomei
    Guo, Yuelu
    Shi, Hui
    Deng, Biping
    Ke, Xiaoyan
    Wu, Tong
    BLOOD, 2021, 138
  • [22] MANAGING RELAPSED/REFRACTORY ACUTE LYMPHOBLASTIC LEUKEMIA (B-ALL) PATIENTS ON A PHASE I TRIAL RECEIVING AUTOLOGOUS CAR (CHIMERIC ANTIGEN RECEPTOR) T-CELLS GENETICALLY MODIFIED TO TARGET B CELL SPECIFIC ANTIGEN CD19
    Quintanilla, Hilda S.
    Miale-Mayer, Donna
    Llerandi, Diane
    ONCOLOGY NURSING FORUM, 2014, 41 (02) : E102 - E103
  • [23] Gene-edited allogeneic CAR19 T cells (UCART19) induce molecular remission ahead of allo-SCT in high risk pediatric patients with CD19+relapsed/refractory B-cell acute lymphoblastic leukemia
    Qasim, Waseem
    Ciocarlie, Oana
    Adams, Stuart
    Inglott, Sarah
    Murphy, Claire
    Rivat, Christine
    Wright, Gary
    Lucchini, Giovanna
    Silva, Juliana
    Rao, Kanchan
    Zinai, Amina
    Binlich, Florence
    Dupouy, Sandra
    Pauly, Jeanne
    Balandraud, Svetlana
    Simon, Flavie
    Konto, Cyril
    Bermingham, Candy
    Chiesa, Robert
    Samarasinghe, Sujith
    Hara, Havinder
    Boyle, Alayna
    Chu, Jan
    Pinner, Danielle
    Amrolia, Persis J.
    Vora, Ajay
    Rao, Anupama
    Ancliffe, Philip
    Veys, Paul
    BONE MARROW TRANSPLANTATION, 2018, 53 : 27 - 28
  • [24] Novel humanized CD19-CAR-T (Now talicabtagene autoleucel, Tali-cel™) cells in relapsed/ refractory pediatric B-acute lymphoblastic leukemia- an open-label single-arm phase-I/Ib study
    Gaurav Narula
    Swaminathan Keerthivasagam
    Hasmukh Jain
    Sachin Punatar
    Akanksha Chichra
    Chetan Dhamne
    Prashant Tembhare
    Papagudi Ganesan Subramanian
    Nikhil Patkar
    Minal Poojary
    Anant Gokarn
    Sumeet Mirgh
    Nishant Jindal
    Albeena Nisar
    Deepali Pandit
    Khushali Pandit
    Alka Dwivedi
    Atharva Karulkar
    Ankesh Kumar Jaiswal
    Aalia Khan
    Shreshtha Shah
    Afrin Rafiq
    Moumita Basu
    Juber Pendhari
    Sweety Asija
    Ambalika Chowdury
    Ankit Banik
    Nirmalya Roy Moulik
    Shyam Srinivasan
    Shilpushp Bhosle
    Sumathi Hiregoudar
    Shashank Ojha
    Lingaraj Nayak
    Jayshree Thorat
    Bhausaheb Bagal
    Manju Sengar
    Navin Khattry
    Shripad Banavali
    Steven Highfill
    Nirali N. Shah
    Rahul Purwar
    Blood Cancer Journal, 15 (1)
  • [25] ZUMA-4: A phase 1/2 multicenter study evaluating the safety and efficacy of KTE-C19 (anti-CD19 CAR T cells) in pediatric and adolescent subjects with relapsed/refractory B-precursor acute lymphoblastic leukemia (r/r ALL).
    Wayne, Alan S.
    Sender, Leonard S.
    Lee, Daniel Warnell
    Handgretinger, Rupert
    Brown, Patrick A.
    Jiang, Yizhou
    Navale, Lynn
    Stout, Shanna
    Aycock, Jeff
    Wiezorek, Jeffrey S.
    Jain, Rajul K.
    JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (15)
  • [26] Haplo-Identical Non-Gene Editing CD7 CAR T-Cells Induced Bone Marrow and Extramedullary Remission in a Pediatric Patient with TP53 Mutated Relapsed and Refractory Early T-Cell Precursor Lymphoblastic Leukemia/Lymphoma after Haploidentical Hematopoietic Stem Cell Transplantation
    Dai, Haiping
    Lin, Yang
    Meng, Huimin
    Cui, Qingya
    Zhu, Wenjuan
    Tang, Xiaowen
    Cui, Wei
    Wu, Depei
    BLOOD, 2021, 138
  • [27] High Rates of Minimal Residual Disease-Negative (MRD-) Complete Responses (CR) in Adult and Pediatric and Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia (R/R ALL) Treated With KTE-C19 (Anti-CD19 Chimeric Antigen Receptor [CAR] T Cells): Preliminary Results of the ZUMA-3 and ZUMA-4 Trials
    Shah, Bijal
    Van Huynh
    Sender, Leonard S.
    Lee, Daniel W., III
    Castro, Januario E.
    Wierda, William G.
    Dietz, Andrew C.
    Schiller, Gary J.
    Kersten, Marie Jose
    Handgretinger, Rupert
    Brown, Patrick
    Gore, Lia
    Goekbuget, Nicola
    Rosenthal, Joseph
    Sabatino, Marianna
    Bot, Adrian
    Rossi, John M.
    Jiang, Yizhou
    Navale, Lynn
    Stout, Shanna
    Aycock, Jeff S.
    Wiezorek, Jeff
    Jain, Rajul
    Wayne, Alan S.
    BLOOD, 2016, 128 (22)