Spleen volume is associated with overt hepatic encephalopathy after transjugular intrahepatic portosystemic shunt in patients with portal hypertension

被引:0
作者
Zhao, Chun-Juan [1 ,2 ]
Ren, Chao [1 ]
Yuan, Zhen [3 ]
Bai, Guo-Hui [1 ]
Li, Jin-Yu [1 ,4 ,5 ]
Gao, Long [4 ,5 ]
Li, Jin-Hui
Duan, Ze-Qi [6 ]
Feng, Dui-Ping [4 ,5 ]
Zhang, Hui [1 ,2 ,7 ,8 ]
机构
[1] Shanxi Med Univ, Coll Med Imaging, 56 Xinjian South Road, Taiyuan 030001, Shanxi, Peoples R China
[2] Shanxi Med Univ, Hosp 1, Dept Radiol, Taiyuan 030001, Shanxi, Peoples R China
[3] Shanxi Med Univ, Sch Publ Hlth, Shanxi Key Lab Environm Hlth Impairment & Prevent, NHC Key Lab Pneumoconiosis,Dept Occupat Hlth, Taiyuan 030001, Shanxi, Peoples R China
[4] Shanxi Med Univ, Hosp 1, Dept Oncol & Vasc Intervent, Taiyuan 030001, Shanxi, Peoples R China
[5] Shanxi Med Univ, Shanxi Prov Clin Res Ctr Intervent Med, Hosp 1, Taiyuan 030001, Shanxi, Peoples R China
[6] Shanxi Med Univ, Clin Med Coll 1, Taiyuan 030001, Shanxi, Peoples R China
[7] Shanxi Med Univ, Hosp 1, Shanxi Key Lab Intelligent Imaging & Nanomed, Taiyuan 030001, Shanxi, Peoples R China
[8] Shanxi Med Univ, Hosp 1, Intelligent Imaging Big Data & Funct Nanoimaging E, Taiyuan 030001, Shanxi, Peoples R China
基金
中国国家自然科学基金;
关键词
Hepatic encephalopathy; Transjugular intrahepatic portosystemic shunt; Spleen volume; Portal hypertension; Cirrhosis; SHEAR-WAVE ELASTOGRAPHY; DIAGNOSTIC-ACCURACY; CIRRHOSIS; LIVER; STIFFNESS;
D O I
10.4240/wjgs.v16.i7.2054
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
BACKGROUND Portal shunt and immune status related to the spleen are related to the occurrence of hepatic encephalopathy (HE). It is unknown whether spleen volume before transjugular intrahepatic portosystemic shunt (TIPS) is related to postoperative HE. AIM To investigate the relationship between spleen volume and the occurrence of HE. METHODS This study included 135 patients with liver cirrhosis who underwent TIPS, and liver and spleen volumes were elevated upon computed tomography imaging. The Kaplan-Meier curve was used to compare the difference in the incidence rate of HE among patients with different spleen volumes. Univariate and multivariate Cox regression analyses were performed to identify the factors affecting overt HE (OHE). Restricted cubic spline was used to examine the shapes of the dose-response association between spleen volumes and OHE risk. RESULTS The results showed that 37 (27.2%) of 135 patients experienced OHE during a 1-year follow-up period. Compared with preoperative spleen volume (901.30 +/- 471.90 cm3), there was a significant decrease in spleen volume after TIPS (697.60 +/- 281.0 cm3) in OHE patients. As the severity of OHE increased, the spleen volume significantly decreased (P < 0.05). Compared with patients with a spleen volume >= 782.4 cm3, those with a spleen volume < 782.4 cm3 had a higher incidence of HE (P < 0.05). Cox regression analysis showed that spleen volume was an independent risk factor for post-TIPS OHE (hazard ratio = 0.494, P < 0.05). Restricted cubic spline model showed that with an increasing spleen volume, OHE risk showed an initial increase and then decrease (P < 0.05). CONCLUSION Spleen volume is related to the occurrence of OHE after TIPS. Preoperative spleen volume is an independent risk factor for post-TIPS OHE.
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页数:12
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