Dual-etiology MAFLD: the interactions between viral hepatitis B, viral hepatitis C, alcohol, and MAFLD

被引：6

作者：

Liu, Chun-Jen ^{[1
,2
,3
,4
]}

Seto, Wai Kay ^{[5
]}

Yu, Ming-Lung ^{[6
,7
,8
,9
,10
]}

机构：

[1] Natl Taiwan Univ, Coll Med, Hepatitis Res Ctr, Taipei, Taiwan

[2] Natl Taiwan Univ Hosp, Taipei, Taiwan

[3] Natl Taiwan Univ, Grad Inst Clin Med, Coll Med, Taipei, Taiwan

[4] Natl Taiwan Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Coll Med, Taipei, Taiwan

[5] Univ Hong Kong, Sch Clin Med, Dept Med, Pok Fu Lam, Hong Kong, Peoples R China

[6] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Coll Med, Ctr Hepatitis Res,Hepatobiliary Div,Dept Internal, Kaohsiung, Taiwan

[7] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Ctr Liquid Biopsy & Cohort Res, Kaohsiung, Taiwan

[8] Natl Sun Yat Sen Univ, Coll Med, Sch Med, Kaohsiung, Taiwan

[9] Natl Sun Yat Sen Univ, Coll Med, Doctoral Program Clin & Expt Med, Kaohsiung, Taiwan

[10] Natl Sun Yat Sen Univ, Ctr Excellence Metab Associated Fatty Liver Dis, Kaohsiung, Taiwan

来源：

HEPATOLOGY INTERNATIONAL | 2024年 / 18卷 / SUPPL 2期

关键词：

Steatosis; Hepatitis B virus; Hepatitis C virus; Fatty liver; Steatohepatitis; Alcoholic liver disease; FATTY LIVER-DISEASE; CONTROLLED ATTENUATION PARAMETER; METABOLIC RISK-FACTORS; BODY-MASS INDEX; HEPATOCELLULAR-CARCINOMA; VIRUS INFECTION; INSULIN-RESISTANCE; STEATOSIS; ASSOCIATION; FIBROSIS;

D O I：

10.1007/s12072-024-10699-x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Metabolic dysfunction-associated fatty liver disease (MAFLD) and viral hepatitis due to chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection are common liver diseases worldwide. Excessive alcohol consumption and alcoholic liver disease (ALD) are also emerging health problems. Therefore, in clinical practice, we may encounter subjects with dual etiology of liver diseases such as coexisting MAFLD/HBV, MAFLD/HCV, and MAFLD/ALD. In this review, we summarize the epidemiology, clinical features, and mutual interactions of MAFLD with coexisting HBV, HCV, or ALD. The impact of MAFLD on the progression of liver diseases and treatment outcomes in patients with chronic viral hepatitis and the clinical questions to be addressed regarding dual MAFLD and ALD are also discussed.

引用

页码：897 / 908

页数：12

共 98 条

[1] Alcohol consumption and metabolic syndrome: Clinical and epidemiological impact on liver disease [J].

Aberg, Fredrik ;

Byrne, Christopher D. ;

Pirola, Carlos J. ;

Mannisto, Ville ;

Sookoian, Silvia .

JOURNAL OF HEPATOLOGY, 2023, 78 (01) :191-206

[2] Development and validation of a model to predict incident chronic liver disease in the general population: The CLivD score [J].

aberg, Fredrik ;

Luukkonen, Panu K. ;

But, Anna ;

Salomaa, Veikko ;

Britton, Annie ;

Petersen, Kasper Meidahl ;

Bojesen, Stig Egil ;

Balling, Mie ;

Nordestgaard, Borge G. ;

Puukka, Pauli ;

Mannisto, Satu ;

Lundqvist, Annamari ;

Perola, Markus ;

Jula, Antti ;

Farkkila, Martti .

JOURNAL OF HEPATOLOGY, 2022, 77 (02) :302-311

[3] Risks of Light and Moderate Alcohol Use in Fatty Liver Disease: Follow-Up of Population Cohorts [J].

Aberg, Fredrik ;

Puukka, Pauli ;

Salomaa, Veikko ;

Mannisto, Satu ;

Lundqvist, Annamari ;

Valsta, Liisa ;

Perola, Markus ;

Farkkila, Martti ;

Jula, Antti .

HEPATOLOGY, 2020, 71 (03) :835-848

[4] Combined Effects of Alcohol and Metabolic Disorders in Patients With Chronic Liver Disease [J].

Aberg, Fredrik ;

Puukka, Pauli ;

Salomaa, Veikko ;

Mannisto, Satu ;

Lundqvist, Annamari ;

Valsta, Liisa ;

Perola, Markus ;

Jula, Antti ;

Farkkila, Martti .

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2020, 18 (04) :995-+

[5] Hepatitis C virus clearance by direct-acting antiviral treatments and impact on insulin resistance in chronic hepatitis C patients [J].

Adinolfi, Luigi E. ;

Nevola, Riccardo ;

Guerrera, Barbara ;

D'Alterio, Giovanni ;

Marrone, Aldo ;

Giordano, Mauro ;

Rinaldi, Luca .

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2018, 33 (07) :1379-1382

[6] Chronic HCV infection is a risk of atherosclerosis. Role of HCV and HCV-related steatosis [J].

Adinolfi, Luigi E. ;

Restivo, Luciano ;

Zampino, Rosa ;

Guerrera, Barbara ;

Lonardo, Amedeo ;

Ruggiero, Laura ;

Riello, Francesco ;

Loria, Paola ;

Florio, Anna .

ATHEROSCLEROSIS, 2012, 221 (02) :496-502

[7] Hepatitis C virus and other Flaviviridae viruses enter cells via low density lipoprotein receptor [J].

Agnello, V ;

Abel, G ;

Elfahal, M ;

Knight, GB ;

Zhang, QX .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (22) :12766-12771

[8] Prevalence and clinical characteristics of patients with metabolic dysfunction-associated fatty liver disease with hepatitis C virus infection-a population-based study [J].

Attia, Dina ;

Alem, Shereen Abdel ;

El-Akel, Wafaa ;

Abdel-Razek, Wael ;

Eslam, Mohamed ;

Fouad, Yasser ;

Waked, Imam .

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2022, 56 (11-12) :1581-1590

[9] A stepwise algorithm using an at-a-glance first-line test for the non-invasive diagnosis of advanced liver fibrosis and cirrhosis [J].

Boursier, Jerome ;

de Ledinghen, Victor ;

Leroy, Vincent ;

Anty, Rodolphe ;

Francque, Sven ;

Salmon, Dominique ;

Lannes, Adrien ;

Bertrais, Sandrine ;

Oberti, Frederic ;

Fouchard-Hubert, Isabelle ;

Cales, Paul .

JOURNAL OF HEPATOLOGY, 2017, 66 (06) :1158-1165

[10] Pan-PPAR agonist lanifibranor improves portal hypertension and hepatic fibrosis in experimental advanced chronic liver disease [J].

Boyer-Diaz, Zoe ;

Aristu-Zabalza, Peio ;

Andres-Rozas, Maria ;

Robert, Claude ;

Ortega-Ribera, Marti ;

Fernandez-Iglesias, Anabel ;

Broqua, Pierre ;

Junien, Jean-Louis ;

Wettstein, Guillaume ;

Bosch, Jaime ;

Gracia-Sancho, Jordi .

JOURNAL OF HEPATOLOGY, 2021, 74 (05) :1188-1199

← 1 2 3 4 5 6 7 8 9 10 →