Marine Pharmacology in 2019-2021: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

被引:9
作者
Mayer, Alejandro M. S. [1 ]
Mayer, Veronica A. [2 ]
Swanson-Mungerson, Michelle [3 ]
Pierce, Marsha L. [1 ]
Rodriguez, Abimael D. [4 ]
Nakamura, Fumiaki [5 ]
Taglialatela-Scafati, Orazio [6 ]
机构
[1] Midwestern Univ, Coll Grad Studies, Dept Pharmacol, 555 31st St, Downers Grove, IL 60515 USA
[2] Aurora Univ, Sch Nursing, Dept Nursing Educ, 347 S Gladstone Ave, Aurora, IL 60506 USA
[3] Midwestern Univ, Coll Grad Studies, Dept Microbiol & Immunol, 555 31st St, Downers Grove, IL 60515 USA
[4] Univ Puerto Rico, Mol Sci Res Ctr, 1390 Ponce Leon Ave, San Juan, PR 00926 USA
[5] Waseda Univ, Res Inst Sci & Engn, 3-4-1 Okubo,Shinjuku Ku, Tokyo 1698555, Japan
[6] Univ Naples Federico II, Dept Pharm, Via D Montesano 49, I-80131 Naples, Italy
关键词
drug; marine; sea; pharmacology; pharmaceutical; review; toxicology; pipeline; preclinical; mechanism; NATURAL-PRODUCTS; INHIBITORY-ACTIVITIES; MONOAMINE-OXIDASE; ALPHA-GLUCOSIDASE; ANTICOAGULANT; ANTIPLATELET; ANTIMALARIAL; ALGAE; INFLAMMATION; FUCOXANTHIN;
D O I
10.3390/md22070309
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The current 2019-2021 marine pharmacology literature review provides a continuation of previous reviews covering the period 1998 to 2018. Preclinical marine pharmacology research during 2019-2021 was published by researchers in 42 countries and contributed novel mechanism-of-action pharmacology for 171 structurally characterized marine compounds. The peer-reviewed marine natural product pharmacology literature reported antibacterial, antifungal, antiprotozoal, antituberculosis, and antiviral mechanism-of-action studies for 49 compounds, 87 compounds with antidiabetic and anti-inflammatory activities that also affected the immune and nervous system, while another group of 51 compounds demonstrated novel miscellaneous mechanisms of action, which upon further investigation, may contribute to several pharmacological classes. Thus, in 2019-2021, a very active preclinical marine natural product pharmacology pipeline provided novel mechanisms of action as well as new lead chemistry for the clinical marine pharmaceutical pipeline targeting the therapy of several disease categories.
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页数:58
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