Effect assessment of traditional Chinese medicine, Guilu Erxian Jiao, in patients with osteoporosis: A case-control study of the Chang gung memorial hospital

被引：1

作者：

Lai, Yuan-Xin ^{[1
]}

Tseng, Chu-Yao ^{[2
]}

Yang, Huang-Yu ^{[3
]}

Yang, Sien-Hung ^{[4
,5
,6
]}

Lee, Pai-Wei ^{[7
]}

Yang, Tsung-Hsien ^{[8
,9
,10
]}

机构：

[1] Chang Gung Mem Hosp, Ctr Tradit Chinese Med, Div Chinese Acupuncture & Traumatol, Taipei Branch, 199,Songshan Dist, Taipei City 10507, Taiwan

[2] Taoyuan Chang Gung Mem Hosp, Div Chinese Acupuncture & Traumatol, Ctr Tradit Chinese Med, 123 Dinghu Rd, Taoyuan 33378, Taiwan

[3] Chang Gung Univ, Chang Gung Mem Hosp, Kidney Res Ctr, Dept Nephrol,Coll Med, 259 Wenhua 1st Rd, Taoyuan City 33302, Taiwan

[4] Chang Gung Mem Hosp, Dept Tradit Chinese Med, Div Chinese Internal Med, Taipei Branch, 199 Songshan Dist, Taipei City 10507, Taiwan

[5] Chang Gung Univ, Sch Chinese Med, 259 Wenhua 1st Rd, Taoyuan City 33302, Taiwan

[6] Chang Gung Univ Sci & Technol, Res Ctr Chinese Herbal Med, 261,Wenhua 1st Rd, Taoyuan City 33302, Taiwan

[7] Chang Gung Mem Hosp, Ctr Big Data Analyt & Stat, 5 Fuxing St, Taoyuan 33305, Taiwan

[8] New Taipei Municipal City TuCheng Hosp, Dept Tradit Chinese Med, 6,Sec 2,Jincheng Rd, New Taipei City 23652, Taiwan

[9] Chang Gung Univ, Coll Med, Dept Physiol & Pharmacol, 259 Wen Hwa 1st Rd, Taoyuan 33302, Taiwan

[10] Chang Gung Mem Hosp, Ctr Comprehens Sports Med, 123 Dinghu Rd, Taoyuan 33378, Taiwan

来源：

EXPLORE-THE JOURNAL OF SCIENCE AND HEALING | 2024年 / 20卷 / 05期

关键词：

Osteoporosis; Guilu Erxian Jiao; traditional Chinese medicine; fracture; TAIWAN; FRACTURES; PREVENTION; DIAGNOSIS; ADULTS; HEALTH;

D O I：

10.1016/j.explore.2024.01.004

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Background: Osteoporosis is a chronic skeletal disease characterized by low bone mass and increased risk of fracture. In Taiwan, Guilu Erxian Jiao (GEJ) is the commonly used formula of Chinese herbal medicines for patients with osteoporosis. However, the effect of GEJ on subsequent fractures in the long term is unclear. This is the first long-term case-control study of the effects of GEJ on the rates of fracture in patients with osteoporosis. Methods: We collected data from January 1, 2000 to December 31, 2019 from the Chang Gung Research Database. We interpreted from the reports of DXA to confirm whether the patients met the criteria for osteoporosis (T score <=-2.5). Eighty-five patients were enrolled in the GEJ group. After two propensity score matchings, 425 patients were identified as the non-GEJ group. We assessed four outcomes to confirm the effects of GEJ in patients with osteoporosis, including the change in the T-score, new occurrences of fractures, cumulative rate of fracture, and how many doses of GEJ need to be administered to effectively reduce fractures Results: There was no significant difference in either the improvement in the T score or the 5-year overall fracture ( p = 0.335) between these two groups. At the fracture-prone sites, the fracture in lumbar vertebrae was less in the GEJ group ( p = 0.034). A total of 600 GEJ pills are required to effectively reduce the incidence of fractures (p value = 0.0039). Conclusions: Patients who take at least 600 GEJ pills would have a decreased fracture risk at fracture-prone sites.

引用

页数：7

共 37 条

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