The impact of high polymerization inulin on body weight reduction in high-fat diet-induced obese mice: correlation with cecal Akkermansia

被引:0
作者
Gan, Liping [1 ]
Zhao, Yifeng [1 ]
Zhang, Zongbao [1 ]
Zhao, Chenkai [1 ]
Li, Jiake [1 ]
Jia, Qingyu [1 ]
Shi, Yusu [1 ]
Wang, Peng [1 ]
Guo, Linna [1 ]
Qiao, Hanzhen [1 ]
Cui, Yaoming [1 ]
Wang, Jinrong [1 ]
机构
[1] Henan Univ Technol, Sch Bioengn, Zhengzhou, Peoples R China
基金
中国国家自然科学基金;
关键词
inulin; polymerization degree; obesity; gut microbiota; high fat diet; Akkermansia; LIPID-METABOLISM; GUT MICROBIOTA; DIVERSITY;
D O I
10.3389/fmicb.2024.1428308
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Obesity presents a significant public health challenge, demanding effective dietary interventions. This study employed a high-fat diet-induced obesity mouse model to explore the impacts of inulin with different polymerization degrees on obesity management. Our analysis reveals that high-degree polymerization inulin (HDI) exhibited a significantly higher oil binding capacity and smaller particle size compared to low-degree polymerization inulin (LDI) (p < 0.05). HDI was more effective than LDI in mitigating body weight gain in high-diet induced obese mice, although neither LDI nor HDI affected blood sugar levels when compared to the high-fat diet control group (p < 0.05). Both HDI and LDI administrations reduced liver weight and enhanced brown adipose tissue thermogenesis compared to the high-fat diet induced control group (p < 0.05). Additionally, HDI suppressed hepatic lipogenesis, resulting in a further reduction in liver triglycerides compared to the high-fat diet-induced obese mice (p < 0.05). Notably, HDI improved gut health by enhancing intestinal morphology and modulating gut microbiota structure. HDI administration notably increased the relative abundance of cecal Akkermansia, a gut microbe associated with improved metabolic health, while LDI showed limited efficacy (p < 0.05 and p > 0.05, respectively). These findings underscore the importance of the structural properties of inulin in its potential to combat obesity and highlight the strategic use of inulin with varying polymerization degrees as a promising dietary approach for obesity management, particularly in its influence on gut microbiota composition and hepatic lipid metabolism regulation.
引用
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页数:16
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