Next-Generation Vaccine Development with Nanomaterials: Recent Advances, Possibilities, and Challenges

被引：4
|
作者：
Shetty, Shamitha [1 ]
Alvarado, Pablo Cordero [1 ]
Pettie, Deleah [1 ]
Collier, Joel H. [1 ]
机构：
[1] Duke Univ, Dept Biomed Engn, Durham, NC 27706 USA
来源：
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING | 2024年 / 26卷
基金：
美国国家卫生研究院;
关键词：
nanomaterials; vaccines; adjuvants; infectious diseases; cancer; inflammatory diseases; OUTER-MEMBRANE VESICLES; IMMUNE-RESPONSES; NANOPARTICLE VACCINES; NLRP3; INFLAMMASOME; MUCOSAL VACCINES; PLATFORM; VIRUS; IMMUNOTHERAPY; NANOVACCINES; DELIVERY;
D O I：
10.1146/annurev-bioeng-110122-124359
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Nanomaterials are becoming important tools for vaccine development owing to their tunable and adaptable nature. Unique properties of nanomaterials afford opportunities to modulate trafficking through various tissues, complement or augment adjuvant activities, and specify antigen valency and display. This versatility has enabled recent work designing nanomaterial vaccines for a broad range of diseases, including cancer, inflammatory diseases, and various infectious diseases. Recent successes of nanoparticle vaccines during the coronavirus disease 2019 (COVID-19) pandemic have fueled enthusiasm further. In this review, the most recent developments in nanovaccines for infectious disease, cancer, inflammatory diseases, allergic diseases, and nanoadjuvants are summarized. Additionally, challenges and opportunities for clinical translation of this unique class of materials are discussed.
引用
收藏
页码：273 / 306
页数：34
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