Elevated serum levels of C-terminal agrin fragment in acetylcholine receptor antibody-positive myasthenia gravis

被引：0

作者：

Yasuda, Manato ^{[1
]}

Uzawa, Akiyuki ^{[1
]}

Onishi, Yosuke ^{[1
,2
]}

Handa, Hideo ^{[1
]}

Akamine, Hiroyuki ^{[1
]}

Ogaya, Etsuko ^{[1
]}

Ozawa, Yukiko ^{[1
,3
]}

Masuda, Hiroki ^{[1
]}

Mori, Masahiro ^{[1
]}

Kuwabara, Satoshi ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Med, Dept Neurol, 1-8-,Inohana,Chuo Ku, Chiba, Chiba 2608670, Japan

[2] NHO Chiba Med Ctr, Dept Neurol, Chiba, Japan

[3] Japanese Narita Red Cross Hosp, Dept Neurol, Narita, Japan

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2024年 / 396卷

关键词：

Agrin; C-terminal agrin fragment; Myasthenia gravis; Neuromuscular junction; Sarcopenia; NEUROMUSCULAR-JUNCTION; SARCOPENIA; LRP4;

D O I：

10.1016/j.jneuroim.2024.578455

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Agrin is essential for neuromuscular junction (NMJ) formation and maintenance. The C-terminal agrin fragment (CAF), generated by neurotrypsin-mediated cleavage of agrin, has been gaining attention as a potential biomarker for sarcopenia. We investigated serum CAF levels in myasthenia gravis (MG), a NMJ disorder. Compared to healthy controls, serum CAF levels were significantly elevated in acetylcholine receptor antibody- positive MG (AChR-MG) patients, but not in muscle-specific kinase antibody-positive MG patients. In AChR-MG, baseline and post-treatment CAF levels inversely correlated with post-treatment MG activities of daily living scores, suggesting that elevated CAF levels may reflect protective mechanisms against AChR-MG pathogenesis, such as improved NMJ regeneration.

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页数：6

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