Clinical and Therapeutic Implications of Clonal Hematopoiesis

被引：5

作者：

Petrone, Giulia ^{[1
]}

Turker, Isik ^{[2
]}

Natarajan, Pradeep ^{[3
,4
,5
]}

Bolton, Kelly L. ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Med, Div Oncol, St. Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Med, Div Cardiol, St Louis, MO USA

[3] Harvard Med Sch, Cardiovasc Res Ctr, Boston, MA USA

[4] Harvard Med Sch, Massachusetts Gen Hosp, Ctr Genom Med, Dept Med, Boston, MA USA

[5] Broad Inst MIT & Harvard, Cardiovasc Dis Initiat, Cambridge, MA USA

来源：

ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS | 2024年 / 25卷

关键词：

clonal hematopoiesis; cardiovascular disease; hematologic malignancies; cellular therapy; management of clonal hematopoiesis; Y-CHROMOSOME LOSS; STEM-CELLS; HEART-FAILURE; SOMATIC MUTATIONS; DRIVER MUTATIONS; ADVERSE OUTCOMES; TET2; MUTATIONS; MOSAIC LOSS; RISK; TRANSPLANTATION;

D O I：

10.1146/annurev-genom-120722-100409

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Clonal hematopoiesis (CH) is an age-related process whereby hematopoietic stem and progenitor cells (HSPCs) acquire mutations that lead to a proliferative advantage and clonal expansion. The most commonly mutated genes are epigenetic regulators, DNA damage response genes, and splicing factors, which are essential to maintain functional HSPCs and are frequently involved in the development of hematologic malignancies. Established risk factors for CH, including age, prior cytotoxic therapy, and smoking, increase the risk of acquiring CH and/or may increase CH fitness. CH has emerged as a novel risk factor in many age-related diseases, such as hematologic malignancies, cardiovascular disease, diabetes, and autoimmune disorders, among others. Future characterization of the mechanisms driving CH evolution will be critical to develop preventative and therapeutic approaches.

引用

页码：329 / 351

页数：23

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