Successful immunosuppressive drug-free immune tolerance induction in hemophilia B with inhibitor and anaphylaxis to factor IX: A case report

被引：0
|
作者：
Bravo, Angeles Palomo [1 ]
Bonilla, Rosario Prieto [1 ]
Rebollar, Daniel Bardan [1 ]
Lopez-Jaime, Francisco Jose [2 ]
Fernandez-Bello, Ihosvany [2 ]
机构：
[1] Hosp Reg Univ Materno Infantil Malaga, Hematol Serv, Malaga, Spain
[2] Hosp Reg Univ Malaga, Hematol Serv, Thrombosis & Hemostasis Unit, Malaga, Spain
来源：
CLINICAL CASE REPORTS | 2024年 / 12卷 / 08期
关键词：
anaphylaxis reaction; desensitization protocol; factor IX-extended half-life product; immune tolerance induction; inhibitors; severe hemophilia B; DESENSITIZATION; MUTATIONS;
D O I：
10.1002/ccr3.9312
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Recommendations advise factor IX desensitization before immune tolerance induction in severe hemophilia B, supported by immunosuppression. A child with inhibitor and anaphylaxis to factor IX showed successful immunosuppression-free immune tolerance induction using very low and slowly increasing doses of a factor IX extended-half-life product. Immune tolerance to factor IX based on this protocol merits further study.
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页数：4
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