Environmental pollutants and male infertility: Effects on CatSper

被引:3
作者
He, Yuxin [1 ]
Wang, Binhui [2 ]
Huang, Jian [3 ,4 ]
Zhang, Dalei [2 ,4 ]
Yuan, Yangyang [3 ,4 ]
机构
[1] Nanchang Univ, Jiangxi Med Coll, Queen Mary Sch, Nanchang 330031, Peoples R China
[2] Nanchang Univ, Sch Basic Med Sci, Nanchang 330006, Peoples R China
[3] Nanchang Univ, Clin Med Expt Ctr, Nanchang 330031, Peoples R China
[4] Nanchang Univ, Jiangxi Prov Key Lab Reprod Physiol & Pathol, Nanchang 330006, Peoples R China
基金
中国国家自然科学基金;
关键词
CatSper channel; Sperm; Male reproduction; Endocrine-disrupting chemicals; Progesterone; HUMAN SPERM FUNCTION; ENDOCRINE-DISRUPTING CHEMICALS; ACTIVATES CATSPER; CADMIUM EXPOSURE; CALCIUM-CHANNELS; PANAX-GINSENG; CA2+ CHANNEL; UV FILTERS; PROGESTERONE; DIETHYLSTILBESTROL;
D O I
10.1016/j.ecoenv.2024.116341
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Infertility is a growing health concern among many couples worldwide. Men account for half of infertility cases. CatSper, a sperm-specific Ca2+ channel, is expressed on the cell membrane of mammalian sperm. CatSper plays an important role in male fertility because it facilitates the entry of Ca2+ necessary for the rapid change in sperm motility, thereby allowing it to navigate the hurdles of the female reproductive tract and successfully locate the egg. Many pollutants present in the environment have been shown to affect the functions of CatSper and sperm, which is a matter of capital importance to understanding and solving male infertility issues. Environmental pollutants can act as partial agonists or inhibitors of CatSper or exhibit a synergistic effect. In this article, we briefly describe the structure, functions, and regulatory mechanisms of CatSper, and discuss the body of literature covering the effects of environmental pollutants on CatSper.
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页数:7
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