NLRP3 inflammasome in atherosclerosis: Mechanisms and targeted therapies

被引：7
作者：
Chen, Pengfei [1 ]
Li, Xia [1 ,2 ]
机构：
[1] Shandong Univ, Marine Coll, Weihai, Peoples R China
[2] Shandong Kelun Pharmaceut Co Ltd, Binzhou, Peoples R China
来源：
FRONTIERS IN PHARMACOLOGY | 2024年 / 15卷
基金：
中国国家自然科学基金;
关键词：
NLRP3; inflammasome; atherosclerosis; mechanisms; targeted therapies; small molecule inhibitors; FOAM CELL-FORMATION; SMOOTH-MUSCLE-CELLS; ACTIVATION; APOPTOSIS; DISEASE; PATHOGENESIS; ASC; AUTOINHIBITION; INTERLEUKIN-1; INHIBITION;
D O I：
10.3389/fphar.2024.1430236
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Atherosclerosis (AS) is the primary pathology behind various cardiovascular diseases and the leading cause of death and disability globally. Recent evidence suggests that AS is a chronic vascular inflammatory disease caused by multiple factors. In this context, the NLRP3 inflammasome, acting as a signal transducer of the immune system, plays a critical role in the onset and progression of AS. The NLRP3 inflammasome is involved in endothelial injury, foam cell formation, and pyroptosis in AS. Therefore, targeting the NLRP3 inflammasome offers a new treatment strategy for AS. This review highlights the latest insights into AS pathogenesis and the pharmacological therapies targeting the NLRP3 inflammasome, focusing on optimal targets for small molecule inhibitors. These insights are valuable for rational drug design and the pharmacological assessment of new targeted NLRP3 inflammasome inhibitors in treating AS.
引用
收藏
页数：18
相关论文
共 173 条
[1]   In vitro and in vivo anti-inflammatory effects of andrographolide [J].
Abu-Ghefreh, Ala'a A. ;
Canatan, Halit ;
Ezeamuzie, Charles I. .
INTERNATIONAL IMMUNOPHARMACOLOGY, 2009, 9 (03) :313-318
[2]   ASC nanobodies to counteract the consequences of inflammasome activation [J].
Adriouch, Sahil ;
Pelegrin, Pablo .
EMBO MOLECULAR MEDICINE, 2022, 14 (06)
[3]   Identification of a novel orally bioavailable NLRP3 inflammasome inhibitor [J].
Agarwal, Sameer ;
Pethani, Jignesh P. ;
Shah, Hardik A. ;
Vyas, Vismit ;
Sasane, Santosh ;
Bhavsar, Harsh ;
Bandyopadhyay, Debdutta ;
Giri, Poonam ;
Viswanathan, Kasinath ;
Jain, Mukul R. ;
Sharma, Rajiv .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 30 (21)
[4]   Antidiabetic drugs and oxidized low-density lipoprotein: A review of anti-atherosclerotic mechanisms [J].
Ahmadi, Ali ;
Panahi, Yunes ;
Johnston, Thomas P. ;
Sahebkar, Amirhossein .
PHARMACOLOGICAL RESEARCH, 2021, 172
[5]   How location and cellular signaling combine to activate the NLRP3 inflammasome [J].
Akbal, Anil ;
Dernst, Alesja ;
Lovotti, Marta ;
Mangan, Matthew S. J. ;
McManus, Roisin M. ;
Latz, Eicke .
CELLULAR & MOLECULAR IMMUNOLOGY, 2022, 19 (11) :1201-1214
[6]   Stem Cell Pluripotency Genes Klf4 and Oct4 Regulate Complex SMC Phenotypic Changes Critical in Late-Stage Atherosclerotic Lesion Pathogenesis [J].
Alencar, Gabriel F. ;
Owsiany, Katherine M. ;
Karnewar, Santosh ;
Sukhavasi, Katyayani ;
Mocci, Giuseppe ;
Nguyen, Anh T. ;
Williams, Corey M. ;
Shamsuzzaman, Sohel ;
Mokry, Michal ;
Henderson, Christopher A. ;
Haskins, Ryan ;
Baylis, Richard A. ;
Finn, Aloke V. ;
McNamara, Coleen A. ;
Zunder, Eli R. ;
Venkata, Vamsidhar ;
Pasterkamp, Gerard ;
Bjorkegren, Johan ;
Bekiranov, Stefan ;
Owens, Gary K. .
CIRCULATION, 2020, 142 (21) :2045-2059
[7]   Mechanisms of fibrous cap formation in atherosclerosis [J].
Alonso-Herranz, Laura ;
Albarran-Juarez, Julian ;
Bentzon, Jacob Fog .
FRONTIERS IN CARDIOVASCULAR MEDICINE, 2023, 10
[8]   Pattern Recognition Receptors and the Host Cell Death Molecular Machinery [J].
Amarante-Mendes, Gustavo P. ;
Adjemian, Sandy ;
Branco, Laura Migliari ;
Zanetti, Larissa C. ;
Weinlich, Ricardo ;
Bortoluci, Karina R. .
FRONTIERS IN IMMUNOLOGY, 2018, 9
[9]   JT002, a small molecule inhibitor of the NLRP3 inflammasome for the treatment of autoinflammatory disorders [J].
Ambrus-Aikelin, Geza ;
Takeda, Katsuyuki ;
Joetham, Anthony ;
Lazic, Milos ;
Povero, Davide ;
Santini, Angelina M. ;
Pranadinata, Rama ;
Johnson, Casey D. ;
McGeough, Matthew D. ;
Beasley, Federico C. ;
Stansfield, Ryan ;
McBride, Christopher ;
Trzoss, Lynnie ;
Hoffman, Hal M. ;
Feldstein, Ariel E. ;
Stafford, Jeffrey A. ;
Veal, James M. ;
Bain, Gretchen ;
Gelfand, Erwin W. .
SCIENTIFIC REPORTS, 2023, 13 (01)
[10]   Systemic Inflammatory Response and Atherosclerosis: The Paradigm of Chronic Inflammatory Rheumatic Diseases [J].
Arida, Aikaterini ;
Protogerou, Athanasios D. ;
Kitas, George D. ;
Sfikakis, Petros P. .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (07)
12345678910