Vancomycin-encapsulated hydrogel loaded microarc-oxidized 3D-printed porous Ti6Al4V implant for infected bone defects: Reconstruction, anti-infection, and osseointegration

被引：2

作者：

Zhang, Teng ^{[1
]}

Zhou, Wenhao ^{[2
]}

Yang, Wanliang ^{[1
]}

Bi, Jingwei ^{[1
]}

Li, Hao ^{[1
]}

Gao, Xianlei ^{[1
]}

Zhang, Baoliang ^{[1
]}

Shi, Guidong ^{[1
]}

Li, Ka ^{[1
]}

Wei, Zhijian ^{[1
,3
]}

Pan, Xin ^{[1
]}

Feng, Shiqing ^{[1
]}

机构：

[1] Shandong Univ, Qilu Hosp, Dept Orthoped, Jinan 250012, Shandong, Peoples R China

[2] Northwest Inst Nonferrous Met Res, Shaanxi Key Lab Biomed Met Mat, Xian 710016, Peoples R China

[3] Tianjin Med Univ, Dept Orthoped, Tianjin Key Lab Spine & Spinal Cord Injury, Int Cooperat Base Spinal Cord Injury,Gen Hosp, Tianjin, Peoples R China

来源：

BIOACTIVE MATERIALS | 2024年 / 42卷

基金：

中国国家自然科学基金;

关键词：

Porous Ti6Al4V implants; Infected bone defects; Anti-infection; Osseointegration; RESISTANT STAPHYLOCOCCUS-AUREUS; TITANIUM; BACTERIAL; ADHESION; OSTEOCLASTOGENESIS; SCAFFOLDS; PHOSPHATE;

D O I：

10.1016/j.bioactmat.2024.07.035

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Infected bone defect is a formidable clinical challenge. Conventional approaches to prevention and treatment for infected bone defects are unsatisfactory. The key elements of the treatment are bone defect reconstruction, antiinfection, and osteogenesis. Conventional treatment methods remain unsatisfactory owing to the absence of composite integrating materials with anti-infective, and osteogenic activities as well as proper mechanical strength at the same time. In this study, we fabricated a vancomycin-encapsulated hydrogel with bacteriaresponsive release properties combined with a shaved porous (submicron-micron) three-dimensional-printed Ti6Al4V implant. The implant surface, modified with submicron-sized pores through microarc oxidation (MAO), showed enhanced osteogenic activity and integrated well with the hydrogel drug release system, enabling sustained vancomycin release. In vitro experiments underscored the commendable antibacterial ability, biosafety, and osteoinductive potential. Effective antibacterial and osteogenic abilities of the implant were further demonstrated in vivo in infected rabbit bone defects. These results showed that the vancomycinencapsulated hydrogel-loaded microarc-oxidized 3D-printed porous Ti6Al4V can repair the infected bone defects with satisfactory anti-infection and osseointegration effects.

引用

页码：18 / 31

页数：14