Diagnosis and management of pediatric acute liver failure: consensus recommendations of the Indian Society of Pediatric Gastroenterology, Hepatology, and Nutrition (ISPGHAN)

被引：2

作者：

Lal, Bikrant Bihari ^{[1
]}

Khanna, Rajeev ^{[1
]}

Sood, Vikrant ^{[1
]}

Alam, Seema ^{[1
]}

Nagral, Aabha ^{[2
,3
]}

Ravindranath, Aathira ^{[4
]}

Kumar, Aditi ^{[5
]}

Deep, Akash ^{[6
]}

Gopan, Amrit ^{[7
]}

Srivastava, Anshu ^{[8
]}

Maria, Arjun ^{[9
]}

Pawaria, Arti ^{[10
]}

Bavdekar, Ashish ^{[11
]}

Sindwani, Gaurav ^{[12
]}

Panda, Kalpana ^{[13
]}

Kumar, Karunesh ^{[14
]}

Sathiyasekaran, Malathi ^{[15
]}

Dhaliwal, Maninder ^{[16
]}

Samyn, Marianne ^{[17
]}

Peethambaran, Maya ^{[18
]}

Sen Sarma, Moinak ^{[8
]}

Desai, Moreshwar S. ^{[19
,20
]}

Mohan, Neelam ^{[21
]}

Dheivamani, Nirmala ^{[22
]}

Upadhyay, Piyush ^{[23
]}

Kale, Pratibha ^{[24
]}

Maiwall, Rakhi ^{[25
]}

Malik, Rohan ^{[26
]}

Koul, Roshan Lal ^{[27
]}

Pandey, Snehavardhan ^{[28
]}

Ramakrishna, Somashekara Hosaagrahara ^{[29
]}

Yachha, Surender Kumar ^{[30
]}

Lal, Sadhna ^{[31
]}

Shankar, Sahana ^{[32
]}

Agarwal, Sajan ^{[33
]}

Deswal, Shivani ^{[34
]}

Malhotra, Smita ^{[35
]}

Borkar, Vibhor ^{[36
]}

Gautam, Vipul ^{[37
]}

Sivaramakrishnan, Viswanathan M. ^{[38
]}

Dhawan, Anil ^{[17
]}

Rela, Mohamed ^{[39
]}

Sarin, Shiv Kumar ^{[25
]}

机构：

[1] Inst Liver & Biliary Sci, Dept Pediat Hepatol, New Delhi 110070, India

[2] Jaslok Hosp & Res Ctr, Dept Gastroenterol, Mumbai, India

[3] Apollo Hosp, Navi Mumbai, India

[4] Apollo BGS Hosp, Dept Pediat Gastroenterol, Mysuru, Karnataka, India

[5] All India Inst Med Sci, Dept Pediat, Bhubaneswar, India

[6] Kings Coll Hosp London, Dept Pediat Intens Care, London, England

[7] Sir HN Reliance Fdn Hosp, Dept Pediat Gastroenterol & Hepatol, Mumbai, India

[8] Sanjay Gandhi Post Grad Inst Med Sci, Dept Pediat Gastroenterol, Lucknow, India

[9] Sir Ganga Ram Hosp, Inst Child Hlth, Div Pediat Gastroenterol Hepatol & Nutr, New Delhi, India

[10] Amrita Inst Med Sci, Dept Pediat Hepatol & Gastroenterol, Faridabad, India

[11] KEM Hosp & Res Ctr, Dept Pediat, Pune, India

[12] Inst Liver & Biliary Sci, Dept Organ Transplant Anesthesia & Crit Care, New Delhi, India

[13] Inst Med Sci & SUM Hosp, Dept Pediat, Bhubaneswar, India

[14] Indraprastha Apollo Hosp, Dept Pediat Gastroenterol & Liver Transplantat, New Delhi, India

[15] Rainbow Childrens Hosp, Dept Paediat Gastroenterol, Chennai, India

[16] Amrita Inst Med Sci, Dept Pediat Intens Care, Faridabad, India

[17] Kings Coll Hosp London, Dept Pediat Hepatol, London, England

[18] VPS Lakeshore Hosp, Dept Pediat Gastroenterol & Hepatol, Kochi, Kerala, India

[19] Baylor Coll Med, Dept Paediat Crit Care & Liver ICU, Houston, TX USA

[20] Texas Childrens Hosp, Houston, TX USA

[21] Medanta Med Hosp, Dept Pediat Gastroenterol & Hepatol, Gurugram, India

[22] Inst Child Hlth & Hosp Children, Dept Paediat Gastroenterol, Chennai, India

[23] Dr Ram Manohar Lohia Inst Med Sci, Dept Pediat, Lucknow, India

[24] Inst Liver & Biliary Sci, Dept Microbiol, New Delhi, India

[25] Inst Liver & Biliary Sci, Dept Hepatol, New Delhi, India

[26] All India Inst Med Sci, Dept Pediat Gastroenterol & Hepatol, New Delhi, India

[27] Inst Liver & Biliary Sci, Dept Neurol, New Delhi, India

[28] Sahyadri Superspecial Hosp Pvt Ltd Pune, Dept Pediat Hepatol & Liver Transplantat, Pune, India

[29] Glenegales Global Hlth City, Dept Pediat Hepatol & Liver Transplantat, Chennai, India

[30] Sakra World Hosp, Dept Pediat Gastroenterol Hepatol & Liver Transpla, Bangalore, India

[31] Postgrad Inst Med Educ & Res PGIMER, Div Pediat Gastroenterol & Hepatol, Chandigarh, India

[32] Narayana Hlth City, Mazumdar Shaw Med Ctr, Dept Pediat, Div Pediat Gastroenterol & Hepatol, Bangalore, India

[33] Gujarat Gastro Hosp, Dept Pediat Gastroenterol & Hepatol, Surat, Gujarat, India

[34] Narayana Hlth, Dept Pediat Gastroenterol Hepatol & Liver Transpla, DLF Phase 3, Gurugram, India

[35] Indraprastha Apollo Hosp, Dept Pediat Gastroenterol & Hepatol, New Delhi, India

[36] Nanavati Max Super Special Hosp, Dept Paediat Hepatol & Gastroenterol, Mumbai, Maharashtra, India

[37] Max Superspecial Hosp, Dept Pediat Gastroenterol Hepatol & Liver Transpla, New Delhi, India

[38] Apollo Childrens Hosp, Dept Paediat Gastroenterol & Hepatol, Chennai, India

[39] Dr Rela Inst & Med Ctr, Dept Liver Transplantat & HPB Hepato Pancreat Bili, Chennai, India

来源：

HEPATOLOGY INTERNATIONAL | 2024年 / 18卷 / 05期

关键词：

Guidelines; Pediatric acute liver failure; Acute liver failure; Non-invasive assessment of cerebral edema; Bridging therapies; Therapeutic plasma exchange; Continuous renal replacement therapy; Molecular adsorbent recirculating system; Diagnosis; Management; Liver transplantation; RENAL REPLACEMENT THERAPY; FULMINANT HEPATIC-FAILURE; CEREBRAL-BLOOD-FLOW; PREDICTING FLUID RESPONSIVENESS; ADSORBENT RECIRCULATING SYSTEM; INTRAVENOUS N-ACETYLCYSTEINE; RANDOMIZED CONTROLLED-TRIAL; HIGH-VOLUME PLASMAPHERESIS; COLLEGE HOSPITAL CRITERIA; ACUTE VIRAL-HEPATITIS;

D O I：

10.1007/s12072-024-10720-3

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Timely diagnosis and management of pediatric acute liver failure (PALF) is of paramount importance to improve survival. The Indian Society of Pediatric Gastroenterology, Hepatology, and Nutrition invited national and international experts to identify and review important management and research questions. These covered the definition, age appropriate stepwise workup for the etiology, non-invasive diagnosis and management of cerebral edema, prognostic scores, criteria for listing for liver transplantation (LT) and bridging therapies in PALF. Statements and recommendations based on evidences assessed using the modified Grading of Recommendations Assessment, Development and Evaluation (GRADE) system were developed, deliberated and critically reappraised by circulation. The final consensus recommendations along with relevant published background information are presented here. We expect that these recommendations would be followed by the pediatric and adult medical fraternity to improve the outcomes of PALF patients.

引用

页码：1343 / 1381

页数：39

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