Polyethylene glycol (PEG-400) Mediated One-pot Green Synthesis of 4,7-Dihydro-2H-pyrazolo[3,4-b]pyridines Under Catalyst-free Conditions

被引：15

作者：

Kerru, Nagaraju ^{[1
]}

Gummidi, Lalitha ^{[1
]}

Maddila, Suresh ^{[1
]}

Jonnalagadda, Sreekantha B. ^{[1
]}

机构：

[1] Univ KwaZulu Natal, Sch Chem & Phys, Westville Campus,Chiltern Hills,Private Bag 54001, ZA-4000 Durban, South Africa

来源：

CHEMISTRYSELECT | 2020年 / 5卷 / 40期

关键词：

Catalyst-free; Multicomponent reaction; One-pot; PEG-400; medium; Pyrazolo[3; 4-b]pyridine; RECYCLABLE REACTION MEDIUM; REUSABLE SOLVENT MEDIUM; MULTICOMPONENT REACTIONS; ORGANIC-SYNTHESIS; POLY(ETHYLENE GLYCOL); SUPERCRITICAL FLUIDS; IONIC LIQUIDS; EFFICIENT; HETEROCYCLES; DERIVATIVES;

D O I：

10.1002/slct.202002538

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Polyethylene glycol (PEG-400) was proved a highly efficient and green solvent reaction medium for the synthesis of series of novel 3,6-dimethyl-4,7-dihydro-2H-pyrazolo[3,4-b]pyridine derivatives with excellent yields by a three-component reaction of 1H-pyrazol-3-amino-5-methyl, various aromatic or heteroaromatic aldehydes and chosen CH-active compounds under catalyst-free conditions via one-pot strategy. This transformation is compatible with a broad diversity of functional group tolerance. Rapid synthesis, mild reaction conditions, high yields, no catalyst or column chromatography, cost-effectiveness and green solvent are the benefits of this protocol.

引用

页码：12407 / 12410

页数：4

共 50 条

[41] Synthesis and biological evaluation of pyrido[3,2,1-ij][1,2,3]triazolo[4,5-c] quinolinones: PEG-400 mediated one-pot reaction under ultrasonic irradiation
Johnpasha, Shaik
Nasipireddy, Venkatarathnam
Haridasyam, Ramesh Babu
Sirassu, Narsimha
POLYCYCLIC AROMATIC COMPOUNDS, 2023,
[42] Acetic Acid-Driven One-Pot Synthesis of 4,7-dihydro-[1,2,3]thiadiazolo[5,4-b]pyridine-6-carboxamides and Pharmacological Evaluations
Bhalodiya, Savan S.
Parmar, Mehul P.
Patel, Chirag D.
Patel, Subham G.
Vala, Disha P.
Suresh, Nandhakumar
Jayachandran, Bhuvaneshwari
Arumugam, Madan Kumar
Narayan, Mahesh
Patel, Hitendra M.
CHEMMEDCHEM, 2025, 20 (02)
[43] One-pot two-step facile synthesis of new 6,7-dihydro-1H-pyrazolo [3,4-b] pyridine-5-carbonitrile hybrids as antimicrobial agents
Tiwari, Shailendra
Ahmad, Akeel
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2019, 58 (12): : 1407 - 1412
[44] One-pot, three-component synthesis of novel coumarinyl-pyrazolo[3,4-b]pyridine-3-carboxylate derivatives using [AcMIm]FeCl4 as recyclable catalyst
Ambati, Srinivasa Rao
Patel, Jeevan Lal
Chandrakar, Komal
Sarkar, Uttam
Penta, Santhosh
Banerjee, Subhash
Varma, Rajender S.
JOURNAL OF MOLECULAR STRUCTURE, 2022, 1268
[45] One-pot, catalyst-free synthesis of novel spiro[indole-3,4′-pyrano[2′,3′:4,5]pyrimido [2,1-b][1,3]benzothiazole] derivatives
Zangouei, Mahdieh
Esmaeili, Abbas Ali
JOURNAL OF CHEMICAL RESEARCH, 2020, 44 (11-12) : 646 - 652
[46] Very Efficient and Rapid Catalyst-free One-pot Three Component Synthesis of 2,5-Dihydro-5-imino-2-methylfuran-3,4-dicarboxylate Derivatives Under Ultrasound Irradiation
Rouhani, Morteza
Ramazani, Ali
Joo, Sang Woo
Hanifehpour, Younes
BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2012, 33 (12) : 4127 - 4130
[47] Amino Functionalized Nano Fe3O4@SiO2 as a Magnetically Green Catalyst for the One-Pot Synthesis of Spirooxindoles Under Mild Conditions
Alemi-Tameh, Fatemeh
Safaei-Ghomi, Javad
Mahmoudi-Hashemi, Mohammad
Monajjemi, Majid
POLYCYCLIC AROMATIC COMPOUNDS, 2018, 38 (03) : 199 - 212
[48] A pot-economical and green synthesis of novel (benzo[d]imidazo[2,1-b]thiazol-3-y1)-2H-chromen-2-one in ethanol PEG-600 under catalyst-free conditions
Balwe, Sandip Gangadhar
Lim, Kwon Taek
Cho, Byung Gwon
Jeong, Yeon Tae
TETRAHEDRON, 2017, 73 (25) : 3564 - 3570
[49] PEG-400 mediated and promoted eco-friendly one-pot synthesis of isoxazolyl pyridines, quinolines and 3-hydroxy-2-oxoindoles through sp3 C-H bond functionalization of methyl aza-arenes
Nagaraju, D.
Kishore, B.
Thirupathaiah, K.
Rajanarendar, E.
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2017, 56 (11): : 1193 - 1199
[50] [PBMIM](FECL4)2: AN EFFECTIVE CATALYST FOR THE ONE-POT SYNTHESIS OF 1, 3-DIHYDROPYRIMIDIN-2--ONES AND THIONES UNDER SOLVENT FREE CONDITIONS
Godajdar, Bijan Mombani
Kiasat, Ali Reza
JOURNAL OF THE CHILEAN CHEMICAL SOCIETY, 2013, 58 (03): : 1850 - 1852

← 1 2 3 4 5 →