Splenic filtration of red blood cells in physiology, malaria and sickle cell disease

被引:0
作者
Sissoko, Abdoulaye [1 ]
Othmene, Yosra Ben [1 ]
Buffet, Pierre [1 ,2 ,3 ]
机构
[1] Univ Paris Cite, Inserm, BIGR, Paris, France
[2] AP HP, Bobigny, France
[3] Univ Paris Cite, Inst Pasteur, Paris, France
关键词
malaria; red blood cell; sickle cell disease; spleen; MEMORY B-CELLS; PLASMODIUM-FALCIPARUM; INTRAVENOUS ARTESUNATE; WASHOUT KINETICS; HUMAN SPLEEN; IN-VITRO; SEQUESTRATION; DEFORMABILITY; ERYTHROCYTES; CLEARANCE;
D O I
10.1097/MOH.0000000000000839
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Purpose of reviewThe human spleen clears the blood from circulating microorganisms and red blood cells (RBCs) displaying alterations. This review analyzes how generic mechanisms by which the spleen senses RBC, such pitting, trapping and erythrophagocytosis, impact the pathogenesis of two major spleen-related diseases, malaria and sickle cell disease (SCD).Recent findingsScintigraphy, functional histology, comparison of circulating and splenic RBC, ex-vivo perfusion of human spleens and in-silico modeling enable relevant exploration of how the spleen retains and processes RBC in health and disease. Iterative cross-validations between medical observations, in-vitro experiments and in-silico modeling point to mechanical sensing of RBC as a central event in both conditions. Spleen congestion is a common pathogenic process explaining anemia and splenomegaly, the latter carrying a risk of severe complications such as acute splenic sequestration crisis and hypersplenism in SCD. Sickling of hemoglobin S-containing RBC may contribute to these complications without necessarily being the trigger.SummaryOngoing progress in the exploration and understanding of spleen-related complications in malaria and SCD open the way to optimized prognosis evaluation and therapeutic applications.
引用
收藏
页码:307 / 314
页数:8
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