Liver Stiffness Evaluation in Chronic Hepatitis C Patients with Cirrhosis before and after Direct-Acting Antivirals

被引:0
作者
Stasi, Cristina [1 ]
Brillanti, Stefano [1 ]
机构
[1] Univ Siena, Dept Med Surg & Neurosci, I-53100 Siena, Italy
关键词
hepatitis C virus; chronic hepatitis C; liver cirrhosis; liver stiffness; non-invasive evaluation; transient elastography; SUSTAINED VIROLOGICAL RESPONSE; FIBROSIS; DISEASE; RECOMMENDATIONS; GUIDELINES; INFECTION; SURVIVAL; THERAPY; MODEL; RISK;
D O I
10.3390/microorganisms12071418
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
After the introduction of direct-acting antivirals, parallel significant clinical progress has been achieved in the assessment of liver fibrosis progression/regression before treatment and during the follow-up of the cirrhotic patients with chronic hepatitis C virus (HCV) infection. The evolution of chronic hepatitis C into liver cirrhosis is correlated with an extensive accumulation of the extracellular matrix, leading to the formation of large amounts of fibrotic tissues that, initially, are concentrated in periportal areas and, in the later stages, surround the nodules of regenerating hepatocytes. The progressive increase in the fibrotic matrix contributes to vascular disturbances (favoring the development of portal hypertension) and to microenvironmental changes. The four clinical stages of liver cirrhosis are predictors for different clinical scenarios. The wide-ranging functions of the liver require different methods for their assessment. The non-invasive evaluation using transient elastography is useful in determining the longitudinal modifications of fibrosis during and after treatment with direct-acting antivirals. The liver stiffness evaluation, known to have a wide range of values in cirrhotic patients, can offer different prognostic implications after sustained virological response. This review discusses the different time points of liver stiffness evaluation that appear to show a more well-defined propensity to identify adequate monitoring schedules for these patients.
引用
收藏
页数:13
相关论文
共 51 条
  • [1] Hepatic fibrosis changes in patients with chronic hepatitis C infection who respond to direct-acting antivirals
    Alswat, Khalid
    Al-Sohaibani, Fahad
    Khathlan, Abdullah
    Bashmail, Ahmad
    Alanazi, Mohammed
    Kurdi, Amr
    Almakadma, Abdul Hakim
    Al-Hamoudi, Waleed
    [J]. ANNALS OF SAUDI MEDICINE, 2022, 42 (02) : 89 - 95
  • [2] [Anonymous], 2014, Guidelines for the screening, care and treatment of persons with hepatitis C infection
  • [3] Changes in Liver Stiffness and Markers of Liver Synthesis and Portal Hypertension following Hepatitis C Virus Eradication in Cirrhotic Individuals
    Armandi, Angelo
    Rosso, Chiara
    Troshina, Giulia
    Perez Diaz Del Campo, Nuria
    Marinoni, Chiara
    Nicolosi, Aurora
    Caviglia, Gian Paolo
    Saracco, Giorgio Maria
    Bugianesi, Elisabetta
    Ciancio, Alessia
    [J]. BIOLOGY-BASEL, 2022, 11 (08):
  • [4] Clinical outcomes and prognostic factors after HCV clearance with DAA in HIV/HCV coinfected patients with advanced Fibrosis/Cirrhosis
    Berenguer, Juan
    Aldamiz-Echevarria, Teresa
    Hontanon, Victor
    Fanciulli, Chiara
    Quereda, Carmen
    Busca, Carmen
    Dominguez, Lourdes
    Hernandez, Cristina
    Vergas, Jorge
    Gaspar, Gabriel
    Garcia-Fraile, Lucio J.
    Diez, Cristina
    De Miguel, Marta
    Bellon, Jose M.
    Banares, Rafael
    Gonzalez-Garcia, Juan
    [J]. HEPATOLOGY, 2024,
  • [5] Child C G, 1964, Major Probl Clin Surg, V1, P1
  • [6] Who Should Not Be Surveilled for HCC Development after Successful Therapy with DAAS in Advanced Chronic Hepatitis C? Results of a Long-Term Prospective Study
    Ciancio, Alessia
    Ribaldone, Davide Giuseppe
    Spertino, Matteo
    Risso, Alessandra
    Ferrarotti, Debora
    Caviglia, Gian Paolo
    Carucci, Patrizia
    Gaia, Silvia
    Rolle, Emanuela
    Sacco, Marco
    Saracco, Giorgio Maria
    [J]. BIOMEDICINES, 2023, 11 (01)
  • [7] GUIDELINES AND GOOD CLINICAL PRACTICE RECOMMENDATIONS FOR CONTRAST ENHANCED ULTRASOUND (CEUS) IN THE LIVER - UPDATE 2012 A WFUMB-EFSUMB INITIATIVE IN COOPERATION WITH REPRESENTATIVES OF AFSUMB, AIUM, ASUM, FLAUS AND ICUS
    Claudon, Michel
    Dietrich, Christoph F.
    Choi, Byung Ihn
    Cosgrove, David O.
    Kudo, Masatoshi
    Nolsoe, Christian P.
    Piscaglia, Fabio
    Wilson, Stephanie R.
    Barr, Richard G.
    Chammas, Maria C.
    Chaubal, Nitin G.
    Chen, Min-Hua
    Clevert, Dirk Andre
    Correas, Jean Michel
    Ding, Hong
    Forsberg, Flemming
    Fowlkes, J. Brian
    Gibson, Robert N.
    Goldberg, Barry B.
    Lassau, Nathalie
    Leen, Edward L. S.
    Mattrey, Robert F.
    Moriyasu, Fuminori
    Solbiati, Luigi
    Weskott, Hans-Peter
    Xu, Hui-Xiong
    [J]. ULTRASOUND IN MEDICINE AND BIOLOGY, 2013, 39 (02) : 187 - 210
  • [8] Evaluation of Long-Term Outcomes of Direct Acting Antiviral Agents in Chronic Kidney Disease Subjects: A Single Center Cohort Study
    Czarnecka, Paulina
    Czarnecka, Kinga
    Tronina, Olga
    Baczkowska, Teresa
    Wyczalkowska-Tomasik, Aleksandra
    Durlik, Magdalena
    Czerwinska, Katarzyna
    [J]. JOURNAL OF CLINICAL MEDICINE, 2023, 12 (10)
  • [9] Natural history and prognostic indicators of survival in cirrhosis: A systematic review of 118 studies
    D'Amico, G
    Garcia-Tsao, G
    Pagliaro, L
    [J]. JOURNAL OF HEPATOLOGY, 2006, 44 (01) : 217 - 231
  • [10] Davidov Y, 2021, ISR MED ASSOC J, V23, P794