Nicotine use during late adolescence and young adulthood is associated with changes in hippocampal volume and memory performance

被引:0
作者
Happer, Joseph P. [1 ]
Courtney, Kelly E. [1 ]
Baca, Rachel E. [1 ]
Andrade, Gianna [1 ]
Thompson, Courtney [1 ]
Shen, Qian [2 ]
Liu, Thomas T. [3 ,4 ]
Jacobus, Joanna [1 ]
机构
[1] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92093 USA
[2] Univ Calif San Diego, Dept Neurosci, San Diego, CA USA
[3] Univ Calif San Diego, Ctr Funct MRI, San Diego, CA USA
[4] Univ Calif San Diego, Dept Radiol, San Diego, CA USA
关键词
hippocampus; memory; nicotine; vaping; adolescence; young adult; FRONTAL CORTICAL THICKNESS; SMOKING ABSTINENCE; CO-USE; CIGARETTE; EXPOSURE; CANNABIS; DEPENDENCE; MARIJUANA; COGNITION; SYMPTOMS;
D O I
10.3389/fnins.2024.1436951
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background With the advent of electronic nicotine delivery systems, the use of nicotine and tobacco products (NTPs) among adolescents and young adults remains high in the US. Use of e-cigarettes additionally elevates the risk of problematic use of other substances like cannabis, which is often co-used with NTPs. However, their effects on brain health, particularly the hippocampus, and cognition during this neurodevelopmental period are poorly understood.Methods Healthy late adolescents/young adults (N = 223) ages 16-22 completed a structural MRI to examine right and left hippocampal volumes. Memory was assessed with the NIH Toolbox Picture Sequence Memory Test (PSMT) and Rey Auditory Verbal Learning Test (RAVLT). Cumulative 6-month NTP and cannabis episodes were assessed and modeled continuously on hippocampal volumes. Participants were then grouped based on 6-month NTP use to examine relationships with the hippocampus and memory: current users (CU) endorsed weekly or greater use; light/abstinent users (LU) endorsed less than weekly; and never users (NU).Results NTP use predicted larger hippocampal volumes bilaterally while cannabis use had no impact nor interacted with NTP use. For memory, larger left hippocampal volumes were positively associated with PSMT performance, RAVLT total learning, short delay and long delay recall for the NU group. In contrast, there was a negative relationship between hippocampal volumes and performances for LU and CU groups. No differences were detected between NTP-using groups.Conclusion These results suggest that the hippocampus is sensitive to NTP exposure during late adolescence/young adulthood and may alter typical hippocampal morphometry in addition to brain-behavior relationships underlying learning and memory processes.
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页数:10
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