A future directions of renal cell carcinoma treatment: combination of immune checkpoint inhibition and carbon ion radiotherapy

被引：1
作者：
Zheng, Zhouhang [1 ,2 ,3 ,4 ]
Yang, Tianci [1 ,2 ,3 ,4 ]
Li, Yixuan [1 ,2 ,3 ,4 ]
Qu, Pei [3 ,4 ,5 ]
Shao, Zhiang [3 ,4 ,5 ]
Wang, Yuan [3 ,4 ,5 ]
Chang, Wei [1 ,2 ]
Umar, Shahzad Muhammad [1 ,2 ]
Wang, Jufang [3 ,4 ,5 ]
Ding, Nan [3 ,4 ,5 ]
Wang, Wei [1 ,2 ]
机构：
[1] Lanzhou Univ, Hosp 2, Dept Urol, Lanzhou, Gansu, Peoples R China
[2] Lanzhou Univ, Clin Med Sch, Lanzhou, Gansu, Peoples R China
[3] Chinese Acad Sci, Inst Modern Phys, Key Lab Space Radiobiol Gansu Prov, Lanzhou, Peoples R China
[4] Chinese Acad Sci, Inst Modern Phys, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou, Peoples R China
[5] Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷
基金：
中国科学院西部之光基金; 芬兰科学院;
关键词：
renal cell carcinoma (RCC); radiotherapy; immunotherapy; carbon ion radiotherapy; combination therapy; CALRETICULIN EXPOSURE; PROSTATE-CANCER; CLINICAL-TRIAL; T-CELLS; RADIATION; IMMUNOTHERAPY; IRRADIATION; DOCETAXEL; NIVOLUMAB; OUTCOMES;
D O I：
10.3389/fimmu.2024.1428584
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Renal cell carcinoma (RCC) is considered radio- and chemo-resistant. Immune checkpoint inhibitors (ICIs) have demonstrated significant clinical efficacy in advanced RCC. However, the overall response rate of RCC to monotherapy remains limited. Given its immunomodulatory effects, a combination of radiotherapy (RT) with immunotherapy is increasingly used for cancer treatment. Heavy ion radiotherapy, specifically the carbon ion radiotherapy (CIRT), represents an innovative approach to cancer treatment, offering superior physical and biological effectiveness compared to conventional photon radiotherapy and exhibiting obvious advantages in cancer treatment. The combination of CIRT and immunotherapy showed robust effectiveness in preclinical studies of various tumors, thus holds promise for overcoming radiation resistance of RCC and enhancing therapeutic outcomes. Here, we provide a comprehensive review on the biophysical effects of CIRT, the efficacy of combination treatment and the underlying mechanisms involved in, as well as its therapeutic potential specifically within RCC.
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页数：11
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