Tissue factor pathway inhibitor-2 (TFPI-2)-an underappreciated partaker in cancer and metastasis

被引：5

作者：

Wojtukiewicz, Marek Z. ^{[1
,2
]}

Mysliwiec, Marta ^{[1
]}

Tokajuk, Anna ^{[2
]}

Kruszewska, Joanna ^{[1
]}

Politynska, Barbara ^{[3
,4
]}

Jamroze, Anmbreen ^{[5
]}

Wojtukiewicz, Anna M. ^{[3
]}

Tang, Dean G. ^{[5
]}

Honn, Kenneth V. ^{[6
,7
,8
]}

机构：

[1] Med Univ Bialystok, Dept Oncol, 12 Ogrodowa, PL-15027 Bialystok, Poland

[2] Comprehens Canc Ctr Bialystok, Dept Clin Oncol, 12 Ogrodowa, PL-15027 Bialystok, Poland

[3] Med Univ Bialystok, Dept Psychol & Philosophy, 37 Szpitalna, PL-15295 Bialystok, Poland

[4] Univ Cambridge, Robinson Coll, Grange Rd, Cambridge CB3 9AN, England

[5] Roswell Pk Comprehens Canc Ctr, Dept Pharmacol & Therapeut, Buffalo, NY 14263 USA

[6] Wayne State Univ, Sch Med, Dept Pathol, Bioact Lipids Res Program, 540 East Canfield Ave, Detroit, MI 48201 USA

[7] Karmanos Canc Inst, 4100 John R St, Detroit, MI 48201 USA

[8] Wayne State Univ, Dept Chem, 5101 Cass Ave, Detroit, MI 48202 USA

来源：

CANCER AND METASTASIS REVIEWS | 2024年 / 43卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Tissue factor pathway inhibitor; Coagulation; Hemostasis; Cancer; Metastasis; Tumor; PREOVULATORY FOLLICULAR-FLUID; ENDOTHELIAL GROWTH-FACTOR; KUNITZ-TYPE DOMAIN; PLACENTAL PROTEIN-5; IN-VITRO; HEPATOCELLULAR-CARCINOMA; GENE-EXPRESSION; TUMOR-GROWTH; IMMUNOHISTOCHEMICAL LOCALIZATION; PROTEASE INHIBITOR;

D O I：

10.1007/s10555-024-10205-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The coagulation system is known to play an important role in cancer development and metastasis, but the precise mechanisms by which it does so remain incompletely understood. With this in mind, we provide an updated overview of the effects of TFPI-2, a protease inhibitor, on cancer development and metastasis. TFPI-2 interacts with the thrombin cascade and also employs other mechanisms to suppress cancer growth and dissemination, which include extracellular matrix stabilization, promotion of caspase-mediated cell apoptosis, inhibition of angiogenesis and transduction of intracellular signals. Down-regulation of TFPI-2 expression is well documented in numerous types of neoplasms, mainly via promoter methylation. However, the exact role of TFPI-2 in cancer progression and possible approaches to up-regulate TFPI-2 expression warrant further studies. Strategies to reactivate TFPI-2 may represent a promising direction for future anticancer studies and therapy development.

引用

页码：1185 / 1204

页数：20

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