The role of adiponectin and its receptor signaling in ocular inflammation-associated diseases

被引：0
|
作者：
Zheng, Jing [1 ,2 ]
Zhang, Wenqiu [1 ,2 ]
Xu, Ran [1 ,2 ]
Liu, Longqian [1 ,2 ]
机构：
[1] Sichuan Univ, West China Hosp, Dept Ophthalmol, 37 Guoxue Xiang, Chengdu 610041, Peoples R China
[2] Sichuan Univ, West China Hosp, Dept Optometry & Visual Sci, 37 Guoxue Xiang, Chengdu 610041, Peoples R China
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2024年 / 717卷
基金：
中国国家自然科学基金;
关键词：
Adiponectin; AdiopoRs; Inflammation; Ocular inflammation-associated diseases; Neovascularization; Immunoregulation; INDUCED CHOROIDAL NEOVASCULARIZATION; HUMAN CEREBROSPINAL-FLUID; DIABETIC-RETINOPATHY; RETINAL NEOVASCULARIZATION; ENDOTHELIAL DYSFUNCTION; SERUM ADIPONECTIN; ADIPOSE-TISSUE; VASCULAR COMPLICATIONS; GRAVES OPHTHALMOPATHY; MACULAR DEGENERATION;
D O I：
10.1016/j.bbrc.2024.150041
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ocular inflammation-associated diseases are leading causes of global visual impairment, with limited treatment options. Adiponectin, a hormone primarily secreted by adipose tissue, binds to its receptors, which are widely distributed throughout the body, exerting powerful physiological regulatory effects. The protective role of adiponectin in various inflammatory diseases has gained increasing attention in recent years. Previous studies have confirmed the presence of adiponectin and its receptors in the eyes. Furthermore, adiponectin and its analogs have shown potential as novel drugs for the treatment of inflammatory eye diseases. This article summarizes the evidence for the interplay between adiponectin and inflammatory eye diseases and provides new perspectives on the diagnostic and therapeutic possibilities of adiponectin.
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页数：13
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