Intratumoral microbiota as cancer therapeutic target

被引:0
|
作者
Guo, Chang [1 ,2 ,3 ]
An, Qi [2 ,4 ]
Zhang, Lu-yao [1 ,2 ]
Wei, Xun-dong [1 ,2 ]
Xu, Jing [1 ,2 ]
Yu, Jiang-yong [1 ,2 ]
Wu, Guo-ju [2 ,4 ]
Ma, Jie [1 ,2 ]
机构
[1] Chinese Acad Med Sci, Beijing Hosp, Ctr Biotherapy, Natl Ctr Gerontol, Beijing 100730, Peoples R China
[2] Chinese Acad Med Sci, Inst Geriatr Med, Beijing 100730, Peoples R China
[3] Univ Chinese Acad Sci, Med Sch, Beijing, Peoples R China
[4] Chinese Acad Med Sci, Beijing Hosp, Natl Ctr Gerontol, Gen Surg Dept, Beijing 100730, Peoples R China
基金
中国国家自然科学基金;
关键词
cancer therapeutic target; elderly population; intratumoral microbiota; FUSOBACTERIUM-NUCLEATUM; COLORECTAL-CANCER; TUMOR; IMPACT; CELLS; DNA;
D O I
10.1002/agm2.12359
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Intratumoral microbiota, which affects the physiological and pathological processes of the host, has attracted increasing attention from researchers. Microbials have been found in normal as well as tumor tissues that were originally thought to be sterile. Intratumoral microbiota is considered to play a significant role in the development of tumors and the reduction of clinical benefits. In addition, intratumoral microbiota are heterogeneous, which have different distribution in various types of tumors, and can influence tumor development through different mechanisms, including genome mutations, inflammatory responses, activated cancer pathways, and immunosuppressive microenvironments. Therefore, eliminating the intratumoral microbiota is considered one of the most promising ways to slow down the tumor progression and improve therapeutic outcomes. In this review, we systematically categorized the intratumoral microbiota and elucidated its role in the pathogenesis and therapeutic response of cancer. We have also described the novel strategies to mitigate the impact of tumor progression. We hope this review will provide new insights for the anti-tumor treatment, particularly for the elderly population, where such insights could significantly enhance treatment outcomes. Three strategies to eliminate intratumoral microbial. Antibiotics can eliminate the intratumoral bacteria and enhancing the effectiveness of tumor treatment; Antibiotic-derived nanoparticles enhance the cancer targeting of drugs and can be designed to combine multiple functions, offering greater clinical benefits. Bacteriophage target particular types of intratumoral microbes, which reduce the impact of antibiotics on normal microbial while improving the immune response and increasing anti-tumor efficacy.image
引用
收藏
页码:636 / 644
页数:9
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