Undescribed Amaryllidaceae Alkaloids from Zephyranthes citrina and Their Cytotoxicity

被引：0

作者：

Kroustkova, Jana ^{[1
]}

Kohelova, Eliska ^{[1
]}

Muthna, Darina ^{[2
]}

Kunes, Jiri ^{[3
]}

Havelek, Radim ^{[2
]}

Vrabec, Rudolf ^{[1
]}

Malanik, Milan ^{[4
]}

Suchankova, Daniela ^{[1
]}

Chlebek, Jakub ^{[1
]}

Jenco, Jaroslav ^{[1
]}

Kosturko, Stefan ^{[1
]}

Cahlikova, Lucie ^{[1
]}

机构：

[1] Charles Univ Prague, Dept Pharmacognosy & Pharmaceut Bot, Hradec Kralove 50003, Czech Republic

[2] Charles Univ Prague, Fac Med Hradec Kralove, Dept Med Biochem, Hradec Kralove 50003, Czech Republic

[3] Charles Univ Prague, Fac Pharm, Dept Bioorgan & Organ Chem, Hradec Kralove 50003, Czech Republic

[4] Masaryk Univ, Fac Pharm, Dept Nat Drugs, Brno 61200, Czech Republic

来源：

JOURNAL OF NATURAL PRODUCTS | 2024年 / 87卷 / 09期

关键词：

CHEMICAL-CONSTITUENTS; APOPTOSIS; CRINUM; HAEMANTHAMINE;

D O I：

10.1021/acs.jnatprod.4c00825

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

This phytochemical study presents the isolation of eight alkaloids from Zephyranthes citrina Baker. The structures of the new alkaloids, zephycitrine (1) and 6-oxonarcissidine (2), were established by analysis of spectroscopic and spectrometric data. Processing the EtOH extract under acid-base conditions yielded the unreported isolation artifacts 3 and 4. This work also provides analytical data for alkaloids not properly described in the literature (5 and 6). The hippeastidine/zephyranine scaffolds in derivatives 3, 4, and 8-10 are also thoroughly discussed. Furthermore, a cytotoxicity screening of 25 Amaryllidaceae alkaloids isolated from Z. citrina was performed. Only the known alkaloids haemanthamine (12), haemanthidine (13), and lycorine (27) showed significant cell growth inhibition.

引用

页码：2317 / 2326

页数：10

共 43 条

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