Preservation of Vocal Function in Amyotrophic Lateral Sclerosis (ALS) Patients Following Percutaneous Dilatational Tracheostomy (PDT) and Adjuvant Therapies

被引：0

作者：

Yoo, Jae-Kook ^{[1
]}

Kwon, Soon-Hee ^{[1
]}

Yoon, Sul-Hee ^{[2
]}

Lee, Jeong-Eun ^{[3
]}

Jeon, Jong-Eun ^{[1
]}

Chung, Je-Hyuk ^{[2
]}

Lee, Sang-Yoon ^{[3
]}

机构：

[1] Rodem Hosp, Dept Neurol, Incheon 22142, South Korea

[2] Rodem Hosp, Dept Internal Med, Incheon 22142, South Korea

[3] Rodem Hosp, Dept Rehabil Med, Incheon 22142, South Korea

来源：

BIOMEDICINES | 2024年 / 12卷 / 08期

关键词：

percutaneous dilatational tracheostomy (PDT); placenta extract injection therapy; low-frequency electrical stimulation; respiratory rehabilitation; swallowing rehabilitation therapy; NONINVASIVE VENTILATION;

D O I：

10.3390/biomedicines12081734

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The study aimed to evaluate the efficacy of percutaneous dilatational tracheostomy (PDT) combined with adjuvant therapies in preserving vocal function in amyotrophic lateral sclerosis (ALS) patients. Methods: We performed a retrospective analysis of 47 ALS patients who underwent PDT at the Rodem Hospital from 2021 to 2023. Post-operatively, these patients were provided with a comprehensive treatment plan that included regenerative injection therapy, low-frequency electrical stimulation, respiratory rehabilitation, and swallowing rehabilitation therapy. Additionally, a balloon reduction program was implemented for effective tracheostomy tube (T-tube) management. The preservation of vocal functions was evaluated 4 weeks following the procedure. Results: While some patients maintained or slightly improved their ALSFRS-R speech scores, the overall trend indicated a decrease in speech scores post-PDT. This suggests that PDT in combination with adjuvant therapies may not universally improve vocal function, but can help maintain it in certain cases. Conclusions: Our findings indicate that PDT combined with mesotherapy, low-frequency electrical stimulation, and swallowing rehabilitation therapy may play a role in maintaining vocal function in limb type ALS patients, though further research is needed to optimize patient management and to validate these results.

引用

页数：15