Rocky Mountain spotted fever is a neglected tropical disease in Latin America

被引:6
作者
Alvarez-Hernandez, Gerardo [1 ]
Paddock, Christopher D. [2 ]
Walker, David H. [3 ]
Valenzuela, Jesus G. [4 ]
Calleja-Lopez, J. R. Tadeo [1 ]
Rivera-Rosas, Cristian Noe [1 ]
Sotelo-Mundo, Rogerio Rafael [5 ]
机构
[1] Univ Sonora, Dept Med & Hlth Sci, Hermosillo, Sonora, Mexico
[2] CDCP, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA USA
[3] Univ Texas Galveston, Dept Pathol, Med Branch, Galveston, TX USA
[4] NIAID, Vector Mol Biol Sect, Lab Malaria & Vector Res, NIH, Rockville, MD USA
[5] Ctr Invest Aimentac & Desarrollo A C, Hermosillo, Sonora, Mexico
来源
PLOS NEGLECTED TROPICAL DISEASES | 2024年 / 18卷 / 07期
关键词
MEXICO; SONORA;
D O I
10.1371/journal.pntd.0012276
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Rocky Mountain spotted fever (RMSF), a severe and extraordinarily lethal infectious disease, has emerged as a widespread public health crisis among predominantly vulnerable populations in several countries of Latin America, particularly evident in northern Mexico. Historically, RMSF has gained less attention than many other tropical infectious diseases, resulting in insufficient allocations of resources and development of capabilities for its prevention and control in endemic regions. We argue that RMSF fulfills accepted criteria for a neglected tropical disease (NTD). The relative neglect of RMSF in most Latin American countries contributes to disparities in morbidity and mortality witnessed in this region. By recognizing RMSF as an NTD, an increased public policy interest, equitable and more appropriate allocation of resources, scientific interest, and social participation can ameliorate the impact of this potentially treatable disease, particularly in vulnerable populations. Rocky Mountain spotted fever (RMSF), a severe and extraordinarily lethal infectious disease, affects predominantly vulnerable populations in several countries of Latin America. The pathogen, Rickettsia rickettsii, is transmitted to humans through the bite of infected hard ticks from the family Ixodidae. When RMSF is not diagnosed or treated promptly, it often results in life-threatening disease and can be rapidly fatal in as many as 30% to 60% of patients. Among survivors, RMSF can result in long-term sequelae, including permanent cognitive deficits and amputations resulting from gangrene of extremities and appendages.Hyperendemic levels of RMSF, witnessed currently in multiple states across northern Mexico, arises from a complex interaction of zoonotic, environmental, and social determinants that pose enormous challenges to health systems and public policies. These same determinants also exist in most Latin American countries, which place the region at great risk for devastating levels of disease. Historically, RMSF has gained far less attention than many other tropical infectious diseases of equivalent or lesser magnitude, resulting in insufficient allocation of resources and limited efforts for its prevention and control. The neglect of RMSF in most Latin American countries contributes to broadening disparities in morbidity and mortality across this region that involve predominantly persons living in poverty, children, and to an increasing degree, pregnant women. Formal recognition of RMSF as a neglected tropical disease is an important step toward reducing the public health burden created by this disease, fostering political and scientific interest and increasing financial resources for the implementation of medical and sanitary interventions.
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收藏
页数:7
相关论文
共 25 条
[21]   Rickettsial infections: A blind spot in our view of neglected tropical diseases [J].
Salje, Jeanne ;
Weitzel, Thomas ;
Newton, Paul N. ;
Varghese, George M. ;
Day, Nicholas .
PLOS NEGLECTED TROPICAL DISEASES, 2021, 15 (05)
[22]   Rocky Mountain spotted fever in Panama: a cluster description [J].
Tribaldos, Maribel ;
Zaldivar, Yamitzel ;
Bermudez, Sergio ;
Samudio, Franklyn ;
Mendoza, Yaxelis ;
Martinez, Alexander A. ;
Villalobos, Rodrigo ;
Eremeeva, Marina E. ;
Paddock, Christopher D. ;
Page, Kathleen ;
Smith, Rebecca E. ;
Pascale, Juan Miguel .
JOURNAL OF INFECTION IN DEVELOPING COUNTRIES, 2011, 5 (10) :737-741
[23]  
World Health Organization, 2022, World health statistics 2022: monitoring health for the SDGs, sustainable development goals
[24]   Rocky Mountain Spotted Fever in a Large Metropolitan Center, Mexico-United Stated Border, 2009-2019 [J].
Zazueta, Oscar E. ;
Armstrong, Paige A. ;
Marquez-Elguea, Adriana ;
Milan, Nestor Saul Hernandez ;
Peterson, Amy E. ;
Ovalle-Marroquin, Diego F. ;
Fierro, Maria ;
Arroyo-Machado, Rodolfo ;
Rodriguez-Lomeli, Moises ;
Trejo-Dozal, Guillermo ;
Paddock, Christopher D. .
EMERGING INFECTIOUS DISEASES, 2021, 27 (06) :1567-1576
[25]   Self-Reported Treatment Practices by Healthcare Providers Could Lead to Death from Rocky Mountain Spotted Fever [J].
Zientek, Jillian ;
Dahlgren, F. Scott ;
McQuiston, Jennifer H. ;
Regan, Joanna .
JOURNAL OF PEDIATRICS, 2014, 164 (02) :416-418