Natural killer cells and anti-tumor immunity

被引：36
|
作者：
Nicholson, Sandra E. [1 ,2 ]
Keating, Narelle [1 ,2 ]
Belz, Gabrielle T. [1 ,2 ]
机构：
[1] Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3052, Australia
[2] Univ Melbourne, Dept Med Biol, Melbourne, Vic 3010, Australia
来源：
MOLECULAR IMMUNOLOGY | 2019年 / 110卷
基金：
澳大利亚国家健康与医学研究理事会;
关键词：
Cancer; ILCs; NK cells; IL-15; SOCS proteins; CIS; SOCS2; INNATE LYMPHOID-CELLS; SMALL-MOLECULE INHIBITOR; MOLONEY LEUKEMIA-CELLS; ROR-GAMMA-T; NK CELLS; PROGNOSTIC-SIGNIFICANCE; SH2-CONTAINING PROTEIN; CYTOTOXIC-CELLS; MICE LACKING; RECEPTOR;
D O I：
10.1016/j.molimm.2017.12.002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Immune checkpoint inhibitors harness the power of the immune system to fight cancer. The clinical success achieved with antibodies against the inhibitory T cell receptors PD-1 and CTLA4 has focused attention on the possibility of manipulating other immune cells, in particular those involved in innate immunity. Here we review the role of innate lymphoid cells (ILCs) and their contribution to tumor immunity. As the prototypical ILC, the natural killer (NK) cell has an intrinsic ability to detect and kill cancer cells. NK cells are dependent on the cytokine interleukin (IL)-15 for their development and effector activity. We discuss the role of the Suppressor of cytokine (SOCS) proteins in negatively regulating IL-15 and NK cell responses and the potential for targeting these small intracellular regulators as new immune checkpoints.
引用
收藏
页码：40 / 47
页数：8
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