Utilizing pigs as a model for studying intestinal barrier function

被引:0
作者
Pieszka, Marek [1 ]
Szczepanik, Kinga [1 ]
Loniewski, Igor [2 ,3 ]
机构
[1] Natl Res Inst Anim Prod, Dept Anim Nutr & Feed Sci, PL-32083 Balice, Poland
[2] Sanprobi Sp Zoo Sp K, Kurza Stopka 5-C, PL-70535 Szczecin, Poland
[3] Pomeranian Med Univ, Dept Biochem Sci, Szczecin, Poland
关键词
DIGESTIVE-TRACT; TIGHT JUNCTIONS; WEANED PIGLETS; GUT MICROBIOTA; ENDOCRINE CELL; FATTY-ACIDS; PERMEABILITY; EXPRESSION; GLUTAMINE; OCCLUDIN;
D O I
10.2478/aoas-2024-0094
中图分类号
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号
0905 ;
摘要
Intestinal permeability has been extensively studied, particularly in gastrointestinal diseases such as inflammatory bowel disease, food allergy, visceral disease, celiac disease, and Crohn's disease. These studies have established that changes in intestinal permeability contribute to the pathogenesis of many gastrointestinal and systemic diseases. While numerous works in the 20th century focused on this topic, it remains relevant for several reasons. Despite the development of new research techniques, it is still unclear whether changes in intestinal permeability are the primary mechanism initiating the disease process or if they occur secondary to an ongoing chronic inflammatory process. Investigating the possibility of stabilizing the intestinal barrier, thereby reducing its permeability preemptively to prevent damage and after the damage has occurred, may offer new therapeutic approaches. Increased intestinal permeability is believed to lead to reduced nutrient absorption, resulting in decreased immunity and production of digestive enzymes.
引用
收藏
页数:28
相关论文
共 137 条
[71]   Stress-induced gastrointestinal barrier dysfunction and its inflammatory effects [J].
Lambert, G. P. .
JOURNAL OF ANIMAL SCIENCE, 2009, 87 (14) :E101-E108
[72]  
Lee F.D., 1990, An. Atlas Text. J. Clinic. Pathol., V43, P521
[73]   Intestinal Permeability Regulation by Tight Junction: Implication on Inflammatory Bowel Diseases [J].
Lee, Sung Hee .
INTESTINAL RESEARCH, 2015, 13 (01) :11-18
[74]   Alteration in intestine tight junction protein phosphorylation and apoptosis is associated with increase in IL-18 levels following alcohol intoxication and burn injury [J].
Li, Xiaoling ;
Akhtar, Suhail ;
Choudhry, Mashkoor A. .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2012, 1822 (02) :196-203
[75]   Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method [J].
Livak, KJ ;
Schmittgen, TD .
METHODS, 2001, 25 (04) :402-408
[76]   Multispecies probiotic affects fecal short-chain fatty acids in postmenopausal women with obesity: A post hoc analysis of a randomized, double-blind, placebo-controlled study [J].
Loniewski, Igor ;
Szulinska, Monika ;
Kaczmarczyk, Mariusz ;
Podsiadlo, Konrad ;
Styburski, Daniel ;
Skonieczna-Zydecka, Karolina ;
Bogdanski, Pawel .
NUTRITION, 2023, 114
[77]   Probiotics in the Management of Mental and Gastrointestinal Post-COVID Symptomes [J].
Loniewski, Igor ;
Skonieczna-Zydecka, Karolina ;
Solek-Pastuszka, Joanna ;
Marlicz, Wojciech .
JOURNAL OF CLINICAL MEDICINE, 2022, 11 (17)
[78]  
Loor JJ, 2001, ANIM RES, V50, P463, DOI 10.1051/animres:2001108
[79]   Claudins in intestines Distribution and functional significance in health and diseases [J].
Lu, Zhe ;
Ding, Lei ;
Lu, Qun ;
Chen, Yan-Hua .
TISSUE BARRIERS, 2013, 1 (03)
[80]  
Ma T.Y., 2018, Physiology of the Gastrointestinal Tract, VSixth, P587, DOI [10.1016/B978-0-12-809954-4.00025-6, DOI 10.1016/B978-0-12-809954-4.00025-6]