Serum and glucocorticoid-regulated kinase 1 (SGK1) as an emerging therapeutic target for cardiac diseases

被引：8
作者：
Yarmohammadi, Fatemeh [1 ]
Karimi, Gholamreza [2 ,3 ]
机构：
[1] Kermanshah Univ Med Sci, Hlth Technol Inst, Med Biol Res Ctr, Kermanshah, Iran
[2] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Iran
[3] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Iran
来源：
PHARMACOLOGICAL RESEARCH | 2024年 / 208卷
关键词：
Cardiopathologic; Hippo pathway; Ion channels; NLRP3; SGK1; SIGNALING PATHWAY; HIPPO PATHWAY; GALLIC ACID; EXPRESSION; INFLAMMATION; HYPERTROPHY; FIBROSIS; MODEL; HOMEOSTASIS; POTASSIUM;
D O I：
10.1016/j.phrs.2024.107369
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Cardiac diseases encompass a wide range of conditions that affect the structure and function of the heart. These conditions are a leading cause of morbidity and mortality worldwide. The serum- and glucocorticoid-inducible kinase 1 (SGK1) is a serine/threonine kinase that plays a significant role in various cellular processes, including cell survival and stress response. Alterations in SGK1 activity can have significant impacts on health and disease. Multiple research findings have indicated that SGK1 is associated with heart disease due to its involvement in cardiac hypertrophy and fibrosis. This article reviews different signaling pathways associated with SGK1 activity in various heart conditions, including the SGK1/NF-kappa B and PI3K/SGK1 pathways.
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页数：10
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