The Role of Exhaled Breath Condensate in Chronic Inflammatory and Neoplastic Diseases of the Respiratory Tract

被引:3
|
作者
Kita, Karolina [1 ]
Gawinowska, Marika [1 ]
Chelminska, Marta [1 ]
Niedoszytko, Marek [1 ]
机构
[1] Med Univ Gdansk, Dept Allergol, 80-210 Gdansk, Poland
基金
英国科研创新办公室;
关键词
exhaled breath condensate (EBC); asthma; COPD; lung cancer; NSCLC; OBSTRUCTIVE PULMONARY-DISEASE; MONITORING OXIDATIVE STRESS; ACID-REACTIVE SUBSTANCES; HYDROGEN-PEROXIDE; NITRIC-OXIDE; LUNG-CANCER; AIRWAY INFLAMMATION; LIPID-PEROXIDATION; INDUCED SPUTUM; ALLERGIC-ASTHMA;
D O I
10.3390/ijms25137395
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Asthma and chronic obstructive pulmonary disease (COPD) are among the most common chronic respiratory diseases. Chronic inflammation of the airways leads to an increased production of inflammatory markers by the effector cells of the respiratory tract and lung tissue. These biomarkers allow the assessment of physiological and pathological processes and responses to therapeutic interventions. Lung cancer, which is characterized by high mortality, is one of the most frequently diagnosed cancers worldwide. Current screening methods and tissue biopsies have limitations that highlight the need for rapid diagnosis, patient differentiation, and effective management and monitoring. One promising non-invasive diagnostic method for respiratory diseases is the assessment of exhaled breath condensate (EBC). EBC contains a mixture of volatile and non-volatile biomarkers such as cytokines, leukotrienes, oxidative stress markers, and molecular biomarkers, providing significant information about inflammatory and neoplastic states in the lungs. This article summarizes the research on the application and development of EBC assessment in diagnosing and monitoring respiratory diseases, focusing on asthma, COPD, and lung cancer. The process of collecting condensate, potential issues, and selected groups of markers for detailed disease assessment in the future are discussed. Further research may contribute to the development of more precise and personalized diagnostic and treatment methods.
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页数:49
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