pH-Responsive supramolecular vesicles for imaging-guided drug delivery: Harnessing aggregation-induced emission

被引：0

作者：

Wang, Xin-Rui ^{[1
]}

Lin, Wei-Xiu ^{[1
]}

Lu, Yi-Long ^{[1
]}

Kuck, Dietmar ^{[2
,3
]}

Xu, Wen-Rong ^{[1
]}

机构：

[1] Hainan Univ, Sch Chem & Chem Engn, Key Lab Adv Mat Trop Isl Resources, Hainan Prov Key Lab Fine Chem,Minist Educ, Haikou 570228, Peoples R China

[2] Bielefeld Univ, Dept Chem, D-33615 Bielefeld, Germany

[3] Bielefeld Univ, Ctr Mol Mat CM2, D-33615 Bielefeld, Germany

来源：

ROYAL SOCIETY OPEN SCIENCE | 2024年 / 11卷 / 09期

基金：

中国国家自然科学基金;

关键词：

supramolecular vesicles; pH-responsive; drug delivery; aggregation-induced emission; imaging-guided; BUCKYBALL JOINTS SYNTHESIS; HOST-GUEST COMPLEXATION; TRIBENZOTRIQUINACENE RECEPTORS; COMPUTATIONAL SIMULATIONS; SUPRA-AMPHIPHILE; C-60; TETRAPHENYLETHYLENE; CONSTRUCTION; RECOGNITION; RELEASE;

D O I：

10.1098/rsos.240664

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The water-soluble tribenzotriquinacene-based hexacarboxylic acid ammonium salt, TBTQ-C 6 , acts as the host component (H) forming host-guest complexes with tetraphenylethylene (TPE)-functionalized monotopic and tetratopic quaternary ammonium derivatives, G1 and G2, to yield supra-amphiphiles. These supra-amphiphiles self-assemble to form pH-responsive fluorescent vesicles, which have allowed us to capitalize on the aggregation-induced emission (AIE) effect for imaging-guided drug delivery systems. These systems exhibit efficient drug loading and pH-responsive delivery capabilities. Upon encapsulation of the anticancer drug doxorubicin (DOX), both the TPE and DOX chromophores undergo dual-fluorescence deactivation due to the energy transfer relay (ETR) effect. Under acidic conditions, the release of DOX interrupts the ETR effect, resulting in the fluorescence recovery of TPE fluorogens and DOX, allowing for real-time visual monitoring of the drug release process. Cytotoxicity experiments confirmed the low toxicity of the unloaded vectors to normal cells, while the DOX-loaded vectors were found to significantly enhance the anticancer activity of DOX against cancer cells in vitro. The AIE-featured supramolecular vesicles presented in this research hold great potential for imaging-guided drug delivery systems.

引用

页数：14

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