Synthesis and biological evaluation of amide derivatives of 1,2,4-thiadiazole-thiazole-pyridine as anticancer agents

A new series of amide derivatives (10a-j) were designed and synthesized and their structures were confirmed by analytical data. Further, all these derivatives (10a-j) were examined for in vitro antitumor activity against four human cancer cell lines like MCF-7 (breast), A549 (lung), Col- 205 (colon) and A2780 (ovarian) by using of the MTT assay. All the derivatives (10a-j) were exhibited remarkable anticancer effects on four cell lines as compared with etoposide used as a positive control. The IC50 values range of tested compounds from 0.11 f 0.051 mu M to 7.42 f 5.89 mu M; whereas, positive control showed IC50 values ranges from 0.17 f 0.034 mu M to 3.34 f 0.152 mu M, respectively. Among these derivatives, four compounds 10a, 10b, 10c & 10d demonstrated more potent activities than the positive control.