Aggregation-Induced Emission-Active Organic Nanoagent with High Photothermal Conversion Efficiency for Near-Infrared Imaging-Guided Tumor Photothermal Therapy

被引:0
|
作者
Zhang, Qiang [1 ]
Li, Enqi [1 ]
Zhang, Youwei [1 ]
Chen, Yunyan [1 ]
Wang, Dongmei [2 ]
Wang, Shaozhen [1 ]
机构
[1] Wannan Med Coll, Inst Synth & Applicat Med Mat, Anhui Prov Engn Res Ctr Dent Mat & Applicat, Dept Pharm, Wuhu 241002, Peoples R China
[2] Wannan Med Coll, Sch Lab Med, Wuhu 241002, Peoples R China
来源
ACS BIOMATERIALS SCIENCE & ENGINEERING | 2024年 / 10卷 / 10期
关键词
aggregation-induced-emission (AIE); photothermaltherapy(PTT); photothermal agents (PTAs); NANOPARTICLES;
D O I
10.1021/acsbiomaterials.4c00959
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
Photothermal therapy (PTT) provides a great prospect for noninvasive cancer therapy. However, it is still highly challenging to construct photothermal agents (PTAs) with the desired performances for imaging-guided PTT applications. Herein, a D-A-D-type naphthalene diamine (NDI)-based photothermal nano-PTAs NDS-BPN NP with near-infrared region (NIR) emission at 822 nm, aggregation-induced emission (AIE), high photothermal conversion efficiency (55.05%), and excellent photothermal stability is successfully designed and prepared through a simple two-step engineering method by using a new AIE molecule NDS-BPN and DSPE-PEG2000 as precursors. The prepared PTT nanoagents NDS-BPN NPs have been further applied for efficient photothermal ablation of cancer cells in vitro and also achieved the NIR fluorescent image-guided PTT tumor therapy in vivo with satisfactory results. We believe that this work provides an attractive NIR AIE NDI-based nano-PTA for the phototherapy of tumors as well as develops the construction strategy of NDI molecular-based photothermal nanoagents with desired performances for imaging-guided PTT.
引用
收藏
页码:6210 / 6217
页数:8
相关论文
共 50 条
  • [31] Biomineralization of Aggregation-Induced Emission-Active Photosensitizers for pH-Mediated Tumor Imaging and Photodynamic Therapy
    Liu, Wei
    Li, Zuhao
    Qiu, Yanqing
    Li, Jun
    Yang, Jinfeng
    Li, Jishan
    ACS APPLIED BIO MATERIALS, 2021, 4 (07): : 5566 - 5574
  • [32] Aggregation Induced Emission Fluorogens Based Nanotheranostics for Targeted and Imaging-Guided Chemo-Photothermal Combination Therapy
    Wang, Ke
    Fan, Xingliang
    Zhao, Lingyun
    Zhang, Xiaoyong
    Zhang, Xiqi
    Li, Zhen
    Yuan, Qian
    Zhang, Qingsong
    Huang, Zengfang
    Xie, Wensheng
    Zhang, Yuanyuan
    Wei, Yen
    SMALL, 2016, 12 (47) : 6568 - 6575
  • [33] One-for-All Phototheranostic Agent Based on Aggregation-Induced Emission Characteristics for Multimodal Imaging-Guided Synergistic Photodynamic/Photothermal Cancer Therapy
    Liu, Luqi
    Wang, Xian
    Wang, Li-Juan
    Guo, Lianqin
    Li, Yanbin
    Bai, Bing
    Fu, Fan
    Lu, Hongguang
    Zhao, Xiaowei
    ACS APPLIED MATERIALS & INTERFACES, 2021, 13 (17) : 19668 - 19678
  • [34] Mesoporous Bamboo Charcoal Nanoparticles as a New Near-Infrared Responsive Drug Carrier for Imaging-Guided Chemotherapy/Photothermal Synergistic Therapy of Tumor
    Dong, Xinghua
    Yin, Wenyan
    Yu, Jie
    Dou, Ruixia
    Bao, Tao
    Zhang, Xiao
    Yan, Liang
    Yong, Yuan
    Su, Chunjian
    Wang, Qing
    Gu, Zhanjun
    Zhao, Yuliang
    ADVANCED HEALTHCARE MATERIALS, 2016, 5 (13) : 1627 - 1637
  • [35] Aggregation-induced emission-active iridium (III)-based mitochondria-targeting nanoparticle for two-photon imaging-guided photodynamic therapy
    Yang, Xucan
    Cheng, Lulu
    Zhao, Yile
    Ma, Haoran
    Song, Haitao
    Yang, Xuanmin
    Wang, Kang-Nan
    Zhang, Yanrong
    JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2024, 659 : 320 - 329
  • [36] Albumin tailoring fluorescence and photothermal conversion effect of near-infrared-II fluorophore with aggregation-induced emission characteristics
    Gao, Shuai
    Wei, Guoguang
    Zhang, Sihang
    Zheng, Binbin
    Xu, Jiaojiao
    Chen, Gaoxian
    Li, Mingwang
    Song, Shaoli
    Fu, Wei
    Xiao, Zeyu
    Lu, Wei
    NATURE COMMUNICATIONS, 2019, 10 (1)
  • [37] Albumin tailoring fluorescence and photothermal conversion effect of near-infrared-II fluorophore with aggregation-induced emission characteristics
    Shuai Gao
    Guoguang Wei
    Sihang Zhang
    Binbin Zheng
    Jiaojiao Xu
    Gaoxian Chen
    Mingwang Li
    Shaoli Song
    Wei Fu
    Zeyu Xiao
    Wei Lu
    Nature Communications, 10
  • [38] Renal-Clearable Nickel-Doped Carbon Dots with Boosted Photothermal Conversion Efficiency for Multimodal Imaging-Guided Cancer Therapy in the Second Near-Infrared Biowindow
    Tian, Boshi
    Liu, Shikai
    Feng, Lili
    Liu, Shaohua
    Gai, Shili
    Dai, Yunlu
    Xie, Lisi
    Liu, Bin
    Yang, Piaoping
    Zhao, Yanli
    ADVANCED FUNCTIONAL MATERIALS, 2021, 31 (26)
  • [39] Fluorination Enhances NIR-II Emission and Photothermal Conversion Efficiency of Phototheranostic Agents for Imaging-Guided Cancer Therapy
    Li, Chunbin
    Jiang, Guoyu
    Yu, Jia
    Ji, Weiwei
    Liu, Lingxiu
    Zhang, Pengfei
    Du, Jian
    Zhan, Chuanlang
    Wang, Jianguo
    Tang, Ben Zhong
    ADVANCED MATERIALS, 2023, 35 (03)
  • [40] Near-infrared small molecule coupled with rigidness and flexibility for high-performance multimodal imaging-guided photodynamic and photothermal synergistic therapy
    Li, Xiaozhen
    Fang, Fang
    Sun, Bo
    Yin, Chao
    Tan, Jihua
    Wan, Yingpeng
    Zhang, Jinfeng
    Sun, Pengfei
    Fan, Quli
    Wang, Pengfei
    Li, Shengliang
    Lee, Chun-Sing
    NANOSCALE HORIZONS, 2021, 6 (02) : 177 - 185