Aggregation-Induced Emission-Active Organic Nanoagent with High Photothermal Conversion Efficiency for Near-Infrared Imaging-Guided Tumor Photothermal Therapy

被引：2

作者：

Zhang, Qiang ^{[1
]}

Li, Enqi ^{[1
]}

Zhang, Youwei ^{[1
]}

Chen, Yunyan ^{[1
]}

Wang, Dongmei ^{[2
]}

Wang, Shaozhen ^{[1
]}

机构：

[1] Wannan Med Coll, Inst Synth & Applicat Med Mat, Anhui Prov Engn Res Ctr Dent Mat & Applicat, Dept Pharm, Wuhu 241002, Peoples R China

[2] Wannan Med Coll, Sch Lab Med, Wuhu 241002, Peoples R China

来源：

ACS BIOMATERIALS SCIENCE & ENGINEERING | 2024年 / 10卷 / 10期

关键词：

aggregation-induced-emission (AIE); photothermaltherapy(PTT); photothermal agents (PTAs); NANOPARTICLES;

D O I：

10.1021/acsbiomaterials.4c00959

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Photothermal therapy (PTT) provides a great prospect for noninvasive cancer therapy. However, it is still highly challenging to construct photothermal agents (PTAs) with the desired performances for imaging-guided PTT applications. Herein, a D-A-D-type naphthalene diamine (NDI)-based photothermal nano-PTAs NDS-BPN NP with near-infrared region (NIR) emission at 822 nm, aggregation-induced emission (AIE), high photothermal conversion efficiency (55.05%), and excellent photothermal stability is successfully designed and prepared through a simple two-step engineering method by using a new AIE molecule NDS-BPN and DSPE-PEG2000 as precursors. The prepared PTT nanoagents NDS-BPN NPs have been further applied for efficient photothermal ablation of cancer cells in vitro and also achieved the NIR fluorescent image-guided PTT tumor therapy in vivo with satisfactory results. We believe that this work provides an attractive NIR AIE NDI-based nano-PTA for the phototherapy of tumors as well as develops the construction strategy of NDI molecular-based photothermal nanoagents with desired performances for imaging-guided PTT.

引用

页码：6210 / 6217

页数：8

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