Tumor Microenvironment-Based Risk Stratification of Oropharyngeal Squamous Cell Carcinoma

被引：0
作者：
Almangush, Alhadi [1 ,2 ,3 ,4 ]
Jouhi, Lauri [5 ,6 ]
Haglund, Caj [6 ,7 ,8 ]
Hagstrom, Jaana [1 ,7 ,9 ]
Makitie, Antti A. [2 ,5 ,6 ,10 ,11 ]
Leivo, Ilmo [12 ,13 ]
机构：
[1] Univ Helsinki, Dept Pathol, Helsinki, Finland
[2] Univ Helsinki, Fac Med, Res Program Syst Oncol, Helsinki, Finland
[3] Univ Turku, Dept Pathol, Turku, Finland
[4] Misurata Univ, Fac Dent, Misurata, Libya
[5] Univ Helsinki, Dept Otorhinolaryngol Head & Neck Surg, Helsinki, Finland
[6] Helsinki Univ Hosp, Helsinki, Finland
[7] Univ Helsinki, Res Programs Unit, Translat Canc Med, Helsinki, Finland
[8] Univ Helsinki, Dept Surg, Helsinki, Finland
[9] Univ Turku, Dept Oral Pathol & Radiol, Turku Univ Hosp, Turku, Finland
[10] Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Ear Nose & Throat Dis, SE-14186 Stockholm, Sweden
[11] Karolinska Univ Hosp, Stockholm, Sweden
[12] Univ Turku, Inst Biomed, Pathol, Turku, Finland
[13] Turku Univ Cent Hosp, Turku, Finland
来源：
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2025年 / 47卷 / 02期
关键词：
oropharyngeal squamous cell carcinoma; prognosis; tumor microenvironment; tumor-infiltrating lymphocytes; tumor-stroma ratio; INFILTRATING LYMPHOCYTES; PATHOLOGISTS; HEAD; TILS; NECK;
D O I：
10.1002/hed.27945
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
BackgroundEvaluation of the prognostic impact of tumor microenvironment (TME) has received attention in recent years. We introduce a TME-based risk stratification for oropharyngeal squamous cell carcinoma (OPSCC).Material and MethodsA total of 182 patients treated for OPSCC at the Helsinki University Hospital were included. TME-based risk stratification was designed combining tumor-stroma ratio and stromal tumor-infiltrating lymphocytes assessed in hematoxylin and eosin-stained sections.ResultsIn multivariable analysis, TME-based risk stratification associated with poor disease-free survival with a hazard ratio (HR) of 2.68 (95% CI 1.11-6.48, p = 0.029). In addition, the proposed risk stratification was associated with poor disease-specific survival (HR 2.687, 95% CI 1.28-5.66, p = 0.009) and poor overall survival (HR 2.21, 95% CI 1.23-3.99, p = 0.008).ConclusionOur TME-based risk stratification provides a powerful prognostic tool that can be used in daily treatment planning of OPSCC together with tumor-related prognostic markers.
引用
收藏
页码：599 / 605
页数：7
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