Immunopathogenesis of Primary Biliary Cholangitis, Primary Sclerosing Cholangitis and Autoimmune Hepatitis: Themes and Concepts

被引：42

作者：

Trivedi, Palak J. ^{[1
,2
,3
,7
]}

Hirschfield, Gideon M. ^{[4
]}

Adams, David H. ^{[1
,2
]}

Vierling, John M. ^{[5
,6
]}

机构：

[1] Univ Birmingham, Natl Inst Hlth Res, Ctr Liver & Gastrointestinal Res, Birmingham Biomed Res Ctr, Birmingham, England

[2] Univ Hosp Birmingham, Liver Unit, Birmingham, England

[3] Univ Birmingham, Inst Translat Med, Birmingham, England

[4] Univ Toronto, Toronto Ctr Liver Dis, Div Gastroenterol & Hepatol, Toronto, ON, Canada

[5] Baylor Coll Med, Dept Med, Sect Gastroenterol & Hepatol, Houston, TX USA

[6] Baylor Coll Med, Dept Surg, Div Abdominal Transplantat, Houston, TX USA

[7] Univ Birmingham, Birmingham, England

来源：

GASTROENTEROLOGY | 2024年 / 166卷 / 06期

基金：

英国惠康基金; “创新英国”项目;

关键词：

Epidemiology; Genetics; Microbiome; Dysbiosis; Bile Acids; Tolerance; Homing; Fibrosis; Transplantation; INFLAMMATORY-BOWEL-DISEASE; REGULATORY T-CELLS; HELPER TYPE 17; D-RECEPTOR POLYMORPHISMS; GENOME-WIDE ASSOCIATION; NATURAL-KILLER-CELLS; FARNESOID-X-RECEPTOR; BILE-ACID; LIVER-DISEASE; GUT MICROBIOTA;

D O I：

10.1053/j.gastro.2024.01.049

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Autoimmune liver diseases include primary biliary cholangitis, primary sclerosing cholangitis, and autoimmune hepatitis, a family of chronic immune-mediated disorders that target hepatocytes and cholangiocytes. Treatments remain nonspecific, variably effective, and noncurative, and the need for liver transplantation is disproportionate to their rarity. Development of effective therapies requires better knowledge of pathogenic mechanisms, including the roles of genetic risk, and how the environment and gut dysbiosis cause immune cell dysfunction and aberrant bile acid signaling. This review summarizes key etiologic and pathogenic concepts and themes relevant for clinical practice and how such learning can guide the development of new therapies for people living with autoimmune liver diseases.

引用

页码：995 / 1019

页数：25

共 200 条

[1] Emerging drugs for the treatment of primary sclerosing cholangitis [J].

Abbas, Nadir ;

Quraishi, Mohammad Nabil ;

Trivedi, Palak .

CURRENT OPINION IN PHARMACOLOGY, 2022, 62 :23-35

[2] Novel antigen-presenting cell imparts Treg-dependent tolerance to gut microbiota [J].

Akagbosu, Blossom ;

Tayyebi, Zakieh ;

Shibu, Gayathri ;

Iza, Yoselin A. Paucar ;

Deep, Deeksha ;

Parisotto, Yollanda Franco ;

Fisher, Logan ;

Pasolli, H. Amalia ;

Thevin, Valentin ;

Elmentaite, Rasa ;

Knott, Maximilian ;

Hemmers, Saskia ;

Jahn, Lorenz ;

Friedrich, Christin ;

Verter, Jacob ;

Wang, Zhong-Min ;

van den Brink, Marcel ;

Gasteiger, Georg ;

Gruenewald, Thomas G. P. ;

Marie, Julien C. ;

Leslie, Christina ;

Rudensky, Alexander Y. ;

Brown, Chrysothemis C. .

NATURE, 2022, 610 (7933) :752-+

[3] Fecal Microbiota Transplantation in Patients With Primary Sclerosing Cholangitis: A Pilot Clinical Trial [J].

Allegretti, Jessica R. ;

Kassam, Zain ;

Carrellas, Madeline ;

Mullish, Benjamin H. ;

Marchesi, Julian R. ;

Pechlivanis, Alexandros ;

Smith, Mark ;

Gerardin, Ylaine ;

Timberlake, Sonia ;

Pratt, Daniel S. ;

Korzenik, Joshua R. .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2019, 114 (07) :1071-1079

[4] T cell targeting and phagocytosis of apoptotic biliary epithelial cells in primary biliary cirrhosis [J].

Allina, Jorge ;

Hu, Bin ;

Sullivan, Daniel M. ;

Fiel, Maria Isabel ;

Thung, Swan N. ;

Bronk, Steven F. ;

Huebert, Robert C. ;

van de Water, Judy ;

LaRusso, Nicholas F. ;

Gershwin, M. E. ;

Gores, Gregory J. ;

Odin, Joseph A. .

JOURNAL OF AUTOIMMUNITY, 2006, 27 (04) :232-241

[5] Environmental triggers in IBD: a review of progress and evidence [J].

Ananthakrishnan, Ashwin N. ;

Bernstein, Charles N. ;

Iliopoulos, Dimitrios ;

Macpherson, Andrew ;

Neurath, Markus F. ;

Ali, Raja A. Raja ;

Vavricka, Stephan R. ;

Fiocchi, Claudio .

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2018, 15 (01) :39-49

[6] Inulin fibre promotes microbiota-derived bile acids and type 2 inflammation [J].

Arifuzzaman, Mohammad ;

Won, Tae Hyung ;

Li, Ting-Ting ;

Yano, Hiroshi ;

Digumarthi, Sreehaas ;

Heras, Andrea F. ;

Zhang, Wen ;

Parkhurst, Christopher N. ;

Kashyap, Sanchita ;

Jin, Wen-Bing ;

Putzel, Gregory Garbes ;

Tsou, Amy M. ;

Chu, Coco ;

Wei, Qianru ;

Grier, Alex ;

Worgall, Stefan ;

Guo, Chun-Jun ;

Schroeder, Frank C. ;

Artis, David .

NATURE, 2022, 611 (7936) :578-+

[7] Epigenomic Evaluation of Cholangiocyte Transforming Growth Factor-β Signaling Identifies a Selective Role for Histone 3 Lysine 9 Acetylation in Biliary Fibrosis [J].

Aseem, Sayed Obaidullah ;

Jalan-Sakrikar, Nidhi ;

Chi, Cheng ;

Navarro-Corcuera, Amaia ;

De Assuncao, Thiago M. ;

Hamdan, Feda H. ;

Chowdhury, Shiraj ;

Banales, Jesus M. ;

Johnsen, Steven A. ;

Shah, Vijay H. ;

Huebert, Robert C. .

GASTROENTEROLOGY, 2021, 160 (03) :889-+

[8] X Chromosome Contribution to the Genetic Architecture of Primary Biliary Cholangitis [J].

Asselta, Rosanna ;

Paraboschi, Elvezia M. ;

Gerussi, Alessio ;

Cordell, Heather J. ;

Mells, George F. ;

Sandford, Richard N. ;

Jones, David E. ;

Nakamura, Minoru ;

Ueno, Kazuko ;

Hitomi, Yuki ;

Kawashima, Minae ;

Nishida, Nao ;

Tokunaga, Katsushi ;

Nagasaki, Masao ;

Tanaka, Atsushi ;

Tang, Ruqi ;

Li, Zhiqiang ;

Shi, Yongyong ;

Liu, Xiangdong ;

Xiong, Ma ;

Hirschfield, Gideon ;

Siminovitch, Katherine A. ;

Carbone, Marco ;

Cardamone, Giulia ;

Duga, Stefano ;

Gershwin, M. Eric ;

Seldin, Michael F. ;

Invernizzi, Pietro .

GASTROENTEROLOGY, 2021, 160 (07) :2483-+

[9] Protective and aggressive bacterial subsets and metabolites modify hepatobiliary inflammation and fibrosis in a murine model of PSC [J].

Awoniyi, Muyiwa ;

Wang, Jeremy ;

Ngo, Billy ;

Meadows, Vik ;

Tam, Jason ;

Viswanathan, Amba ;

Lai, Yunjia ;

Montgomery, Stephanie ;

Farmer, Morgan ;

Kummen, Martin ;

Thingholm, Louise ;

Schramm, Christoph ;

Bang, Corinna ;

Franke, Andre ;

Lu, Kun ;

Zhou, Huiping ;

Bajaj, Jasmohan S. ;

Hylemon, Phillip B. ;

Ting, Jenny ;

Popov, Yury, V ;

Hov, Johannes Roksund ;

Francis, Heather L. ;

Sartor, Ryan Balfour .

GUT, 2023, 72 (04) :671-685

[10] Distinct gut microbiota profiles in patients with primary sclerosing cholangitis and ulcerative colitis [J].

Bajer, Lukas ;

Kverka, Miloslav ;

Kostovcik, Martin ;

Macinga, Peter ;

Dvorak, Jiri ;

Stehlikova, Zuzana ;

Brezina, Jan ;

Wohl, Pavel ;

Spicak, Julius ;

Drastich, Pavel .

WORLD JOURNAL OF GASTROENTEROLOGY, 2017, 23 (25) :4548-4558

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