A Tetrad Catastrophe: Paraneoplastic Syndrome With Abducens Palsy, Intracranial Hypertension, and Optic Neuropathy in Primary Lung Cancer

被引：0

作者：

Chandran, Venushia ^{[1
,2
]}

Masnon, Nurul Ain ^{[3
]}

Nasaruddin, Rona A. ^{[1
]}

Hamzah, Jemaima Che ^{[1
]}

Mohmood, Adzleen ^{[4
]}

Aziz, Andik Fadilah Abdul ^{[5
]}

机构：

[1] Natl Univ Malaysia, Fac Med, Ophthalmol, Kuala Lumpur, Malaysia

[2] Minist Hlth Malaysia, Hosp Kuala Lumpur, Ophthalmol, Kuala Lumpur, Malaysia

[3] Kuala Lumpur Hosp, Ophthalmol, Kuala Lumpur, Malaysia

[4] Univ Putra Malaysia, Hosp Sultan Abdul Aziz Shah, Ophthalmol, Kuala Lumpur, Malaysia

[5] Natl Canc Inst, Nucl Med, Putrajaya, Malaysia

来源：

CUREUS JOURNAL OF MEDICAL SCIENCE | 2024年 / 16卷 / 08期

关键词：

lung cancer; abducens palsy; optic neuropathy; intracranial hypertension; paraneoplastic syndrome;

D O I：

10.7759/cureus.67335

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report a unique case of paraneoplastic syndrome (PS) associated with primary lung cancer. A 57-year-old woman experienced headaches and bilateral visual loss one month after the onset of isolated right abducens palsy. Examination revealed bilateral poor visual acuity (VA), papilledema, and persistent right abducens palsy. Neuroimaging was normal. Lumbar puncture revealed high cerebrospinal fluid (CSF) opening pressure and protein levels. She was started on acetazolamide and pulse methylprednisolone followed by oral corticosteroids. Her abducens nerve palsy resolved, but her VA deteriorated. Anti-Hu and anti-CV2 were positive. A positron emission tomography (PET) scan revealed primary lung cancer, and she died six months after her initial presentation. This case demonstrated that PS poses a diagnostic challenge and may be associated with poor prognosis.

引用

页数：5

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