Integrating amyloid and tau imaging with proteomics and genomics in Alzheimer's disease

被引：11

作者：

Vilkaite, Gabriele ^{[1
]}

Vogel, Jacob ^{[1
]}

Mattsson-Carlgren, Niklas ^{[2
,3
,4
]}

机构：

[1] Lund Univ, Dept Clin Sci Malmo, SciLifeLab, Lund, Sweden

[2] Lund Univ, Dept Clin Sci Malmo, Clin Memory Res Unit, Lund, Sweden

[3] Lund Univ, Skanene Univ Hosp, Dept Neurol, Lund, Sweden

[4] Lund Univ, Wallenberg Ctr Mol Med, Lund, Sweden

来源：

CELL REPORTS MEDICINE | 2024年 / 5卷 / 09期

基金：

瑞典研究理事会;

关键词：

POLYGENIC RISK SCORE; WIDE ASSOCIATION; PET; DEPOSITION; BETA; PATHOLOGY; LOCI; SUSCEPTIBILITY; METAANALYSIS; RESILIENCE;

D O I：

10.1016/j.xcrm.2024.101735

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Alzheimer's disease (AD) is the most common neurodegenerative disease and is characterized by the aggregation of R-amyloid (AR) and tau in the brain. Breakthroughs in disease-modifying treatments targeting AR bring new hope for the management of AD. But to effectively modify and someday even prevent AD, a better understanding is needed of the biological mechanisms that underlie and link AR and tau in AD. Developments of high-throughput omics, including genomics, proteomics, and transcriptomics, together with molecular imaging of AR and tau with positron emission tomography (PET), allow us to discover and understand the biological pathways that regulate the aggregation and spread of AR and tau in living humans. The field of integrated omics and PET studies of AR and tau in AD is growing rapidly. We here provide an update of this field, both in terms of biological insights and in terms of future clinical implications of integrated omics-molecular imaging studies.

引用

页数：16

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