Diagnostic Accuracy of Urinary Biomarkers in Periodontitis: A Systematic Review and Meta-Analysis

被引:0
作者
Fratini, Adriano [1 ]
Izzetti, Rossana [2 ]
Riccetti, Nicola [3 ]
Gennai, Stefano [2 ]
Graziani, Filippo [2 ]
Marchetti, Enrico [1 ]
机构
[1] Univ Aquila, Dept Life Hlth & Environm Sci, I-67100 Laquila, Italy
[2] Univ Pisa, Dept Surg Med & Mol Pathol & Crit Care Med, I-56126 Pisa, Italy
[3] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Med Biostat Epidemiol & Informat, Mainz, Germany
关键词
GINGIVAL CREVICULAR FLUID; CONSENSUS REPORT; BONE METABOLISM; RENAL-FUNCTION; GLOBAL BURDEN; NEOPTERIN; SALIVA; DISEASE; ACTIVATION; MARKER;
D O I
10.1155/2024/9769772
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Background. Biomarkers can be measured in various biological samples. Urine is among the most useful biofluids for routine testing, and several experimental and clinical studies support its role as a tool for the diagnosis and prevention of various diseases. The present systematic review aimed to examine periodontitis-specific urine biomarkers that could have a diagnostic relevance and to provide a qualitative assessment of the current literature. Materials and Methods. Relevant studies identified from PubMed, Embase, Cochrane Library, and Scopus databases were examined to answer the following PECO question: "Could the concentration of specific metabolites in the urine be related to periodontal health and what is their diagnostic accuracy?". Quality of included studies was rated using ROBINS-I tool. Meta-analysis was conducted on available quantitative data. Results. After the screening of 768 titles, five studies were included in qualitative synthesis. The studies included referred to the evaluation of 8-hydroxy-2 '-deoxyguanosine (8-OHdG) and neopterin. Meta-analysis was conducted for neopterin concentration on data available in four studies involving 129 participants. Higher concentrations of neopterin were found in periodontitis-affected patients compared to controls and patients treated for periodontitis. Conclusions. The literature appears controversial in attributing a role to neopterin and 8-OHdG as periodontal biomarkers, highlighting the need for further clinical studies on this topic. While some studies report variations in 8-OHdG and neopterin levels in periodontally affected patients versus either controls or periodontally treated patients, the level of evidence appears still limited to draw firm conclusions (PROSPERO CRD42020222681).
引用
收藏
页数:12
相关论文
共 50 条
[41]   The Effect of Photodynamic Therapy for Periodontitis: A Systematic Review and Meta-Analysis [J].
Azarpazhooh, Amir ;
Shah, Prakesh S. ;
Tenenbaum, Howard C. ;
Goldberg, Michael B. .
JOURNAL OF PERIODONTOLOGY, 2010, 81 (01) :4-14
[42]   Biomarkers in retinopathy of prematurity: a systematic review and meta-analysis [J].
Almutairi, Mariam ;
Chechalk, Katherine ;
Deane, Emelia ;
Fox, Rebecca ;
Janes, Ava ;
Maguire-Henry, Tidgh ;
McCabe, Devin ;
O'Connor, Cole ;
Quirk, Joseph ;
Swan, Evan ;
White, Katherine ;
McCreery, Kathryn ;
Isweisi, Eman ;
Stewart, Philip ;
Branagan, Aoife ;
Roche, Edna F. ;
Meehan, Judith ;
Molloy, Eleanor J. .
FRONTIERS IN PEDIATRICS, 2024, 12
[43]   Biomarkers in psoriatic arthritis: A meta-analysis and systematic review [J].
Wirth, Theo ;
Balandraud, Nathalie ;
Boyer, Laurent ;
Lafforgue, Pierre ;
Pham, Thao .
FRONTIERS IN IMMUNOLOGY, 2022, 13
[44]   Oxidative stress-related biomarkers in saliva and gingival crevicular fluid associated with chronic periodontitis: A systematic review and meta-analysis [J].
Chen, Mengmeng ;
Cai, Wenjin ;
Zhao, Shufan ;
Shi, Lixi ;
Chen, Yang ;
Li, Xumin ;
Sun, Xiaoyu ;
Mao, Yixin ;
He, Bing ;
Hou, Yubo ;
Zhou, Yu ;
Zhou, Qiaozhen ;
Ma, Jianfeng ;
Huang, Shengbin .
JOURNAL OF CLINICAL PERIODONTOLOGY, 2019, 46 (06) :608-622
[45]   Oxidative stress-related biomarkers in chronic periodontitis patients with or without type 2 diabetes: A systematic review and meta-analysis [J].
Chen, Sisi ;
Gao, Xiang ;
Song, Jinlin .
JOURNAL OF PERIODONTAL RESEARCH, 2023, 58 (04) :780-790
[46]   Evaluating the potential of matrix metalloproteinase as a diagnostic biomarker in rheumatoid arthritis and periodontitis: A systematic review and meta-analysis [J].
Batool, Aimen ;
Vaithilingam, Rathna Devi ;
Hassan, Norul Husna Mohamad ;
Safii, Syarida Hasnur ;
Saub, Roslan .
MEDICINE, 2023, 102 (41) :E35340
[47]   Panels of circulating microRNAs as potential diagnostic biomarkers for breast cancer: a systematic review and meta-analysis [J].
Nguyen, Thu H. N. ;
Nguyen, Thanh T. N. ;
Nguyen, Tran T. M. ;
Nguyen, Le H. M. ;
Huynh, Luan H. ;
Phan, Hoang N. ;
Nguyen, Hue T. .
BREAST CANCER RESEARCH AND TREATMENT, 2022, 196 (01) :1-15
[48]   Circulating miRNAs as Auxiliary Diagnostic Biomarkers for Multiple Myeloma: A Systematic Review, Meta-Analysis, and Recommendations [J].
Xiang, Yunhui ;
Zhang, Liuyun ;
Xiang, Pinpin ;
Zhang, Juan .
FRONTIERS IN ONCOLOGY, 2021, 11
[49]   Diagnostic capability of salivary biomarkers in the assessment of head and neck cancer: A systematic review and meta-analysis [J].
Silva Guerra, Eliete Neves ;
Acevedo, Ana Carolina ;
Leite, Andre Ferreira ;
Gozal, David ;
Chardin, Helene ;
Canto, Graziela De Luca .
ORAL ONCOLOGY, 2015, 51 (09) :805-818
[50]   Increased of IL-18 levels are associated with periodontitis: a systematic review and meta-analysis [J].
Alarcon-Sanchez, Mario Alberto ;
Romero-Castro, Norma Samanta ;
Becerra-Ruiz, Julieta Sarai ;
Romero-Servin, Selenne ;
Heboyan, Artak .
BMC ORAL HEALTH, 2024, 24 (01)