Fibroblast growth factor 2

被引：3
|
作者：
Nickle, Audrey [1 ,2 ]
Ko, Sebastian [1 ,2 ]
Merrill, Amy E. [1 ,2 ]
机构：
[1] Univ Southern Calif, Ctr Craniofacial Mol Biol, Ostrow Sch Dent, Dept Biomed Sci, Los Angeles, CA 90033 USA
[2] Univ Southern Calif, Keck Sch Med, Dept Biochem & Mol Med, Los Angeles, CA 90033 USA
来源：
DIFFERENTIATION | 2024年 / 139卷
基金：
美国国家卫生研究院;
关键词：
HIGH-MOLECULAR-WEIGHT; HEPARAN-SULFATE PROTEOGLYCANS; ALTERNATIVE TRANSLATION INITIATION; NEURAL CREST CELLS; MESSENGER-RNA; RECEPTOR-BINDING; GENE-EXPRESSION; FACTOR FGF; NUCLEAR-LOCALIZATION; MICE LACKING;
D O I：
10.1016/j.diff.2023.10.001
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Fibroblast Growth Factor 2 (FGF2), also known as basic fibroblast growth factor, is a potent stimulator of growth and differentiation in multiple tissues. Its discovery traces back over 50 years ago when it was first isolated from bovine pituitary extracts due to its ability to stimulate fibroblast proliferation. Subsequent studies investigating the genomic structure of FGF2 identified multiple protein isoforms, categorized as the low molecular weight and high molecular weight FGF2. These isoforms arise from alternative translation initiation events and exhibit unique molecular and cellular functions. In this concise review, we aim to provide an overview of what is currently known about the structure, expression, and functions of the FGF2 isoforms within the contexts of development, homeostasis, and disease.
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页数：9
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