Dental pulp stem cells - A basic research and future application in regenerative medicine

被引：3

作者：

Stefanska, Katarzyna ^{[1
,2
]}

Volponi, Ana Angelova ^{[3
]}

Kulus, Magdalena ^{[4
]}

Wasko, Jadwiga ^{[1
]}

Farzaneh, Maryam ^{[5
]}

Grzelak, Joanna ^{[6
]}

Azizidoost, Shirin ^{[7
]}

Mozdziak, Paul ^{[8
]}

Bukowska, Dorota ^{[9
]}

Antosik, Pawel ^{[4
]}

Zabel, Maciej ^{[10
,11
]}

Podhorska-Okolow, Marzenna ^{[12
]}

Dziegiel, Piotr ^{[10
]}

Szczesniak, Marta ^{[13
,14
,15
]}

Woszczyk, Maria ^{[15
,16
]}

Kempisty, Bartosz ^{[4
,6
,16
,17
,18
]}

机构：

[1] Celliv 3 SA, PL-61623 Poznan, Poland

[2] Poznan Univ Med Sci, Dept Histol & Embryol, PL-60781 Poznan, Poland

[3] Kings Coll London, Ctr Craniofacial & Regenerat Biol, London WC2R 2LS, England

[4] Nicolaus Copernicus Univ Torun, Inst Vet Med, Dept Vet Surg, PL-87100 Torun, Poland

[5] Ahvaz Jundishapur Univ Med Sci, Fertil Infertil & Perinatol Res Ctr, Ahvaz, Iran

[6] Wroclaw Med Univ, Fac Med, Dept Human Morphol & Embryol, Div Anat, PL-50368 Wroclaw, Poland

[7] Ahvaz Jundishapur Univ Med Sci, Atherosclerosis Res Ctr, Ahvaz, Iran

[8] North Carolina State Univ, Prestage Dept Poultry Sci, Raleigh, NC 27695 USA

[9] Nicolaus Copernicus Univ Torun, Inst Vet Med, Dept Diagnost & Clin Sci, PL-87100 Torun, Poland

[10] Wroclaw Med Univ, Fac Med, Dept Human Morphol & Embryol, Div Histol & Embryol, PL-50368 Wroclaw, Poland

[11] Univ Zielona Gora, Div Anat & Histol, PL-65046 Zielona Gora, Poland

[12] Wroclaw Med Univ, Dept Human Morphol & Embryol, Div Ultrastruct Res, PL-50368 Wroclaw, Poland

[13] Poznan Univ Med Sci, Dept Diagnost, Bukowska 70, PL-60812 Poznan, Poland

[14] Poznan Univ Med Sci, Dept Maxillofacial Surg, Przybyszewskiego 49, PL-60355 Poznan, Poland

[15] WSPL SP ZOZ, Ul Szylinga 1, Poznan, Poland

[16] North Carolina State Univ, Coll Agr & Life Sci, Raleigh, NC 27695 USA

[17] Univ Hosp, Ctr Assisted Reprod, Dept Obstet & Gynecol, Brno, Czech Republic

[18] Masaryk Univ, Brno, Czech Republic

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2024年 / 178卷

关键词：

Dental pulp; Stem cells; Signaling pathways; Non-coding RNAs; OSTEOGENIC DIFFERENTIATION; ODONTOGENIC DIFFERENTIATION; OSTEO/ODONTOGENIC DIFFERENTIATION; NONCODING RNAS; BONE DEFECTS; IN-VITRO; EXPRESSION; PROMOTES; PROLIFERATION; TISSUES;

D O I：

10.1016/j.biopha.2024.116990

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Dental pulp is a valuable and accessible source of stem cells (DPSCs) with characteristics similar to mesenchymal stem cells. DPSCs can regenerate a range of tissues and their potential for clinical application in regenerative medicine is promising. DPSCs have been found to express low levels of Class II HLA-DR (MHC) molecules, making them potential candidates for allogeneic transplantation without matching the donor's tissue. Research on the correlation between non-coding RNAs (ncRNAs) and human dental pulp stem cells (DPSCs) provides promising insights into the use of these cells in clinical settings for a wide range of medical conditions. It is possible to use a number of ncRNAs in order to restore the functional role of downregulated ncRNAs that are correlated with osteoblastogenesis, or to suppress the functional role of overexpressed ncRNAs associated with osteoclast differentiation in some cases.

引用

页数：14

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