Telomeres and SIRT1 as Biomarkers of Gamete Oxidative Stress, Fertility, and Potential IVF Outcome

被引：1

作者：

Panczyszyn, Anna ^{[1
]}

Boniewska-Bernacka, Ewa ^{[1
]}

Wertel, Iwona ^{[2
]}

Sadakierska-Chudy, Anna ^{[3
]}

Goc, Anna ^{[1
]}

机构：

[1] Univ Opole, Inst Med Sci, Fac Med, Dept Biol & Genet, Oleska 48, PL-45052 Opole, Poland

[2] Med Univ Lublin, Independent Lab Canc Diagnost & Immunol, Chodzki 1, PL-20093 Lublin, Poland

[3] Andrzej Frycz Modrzewski Krakow Univ, Fac Med & Hlth Sci, Dept Genet, Coll Medicum, Gustawa Herlinga Grudzinskiego 1, PL-30705 Krakow, Poland

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 16期

关键词：

sirtuin; 1; telomeres; oxidative stress; fertility; IN-VITRO FERTILIZATION; DNA-DAMAGE RESPONSE; KAPPA-B P50/P65; MALE GERM-CELL; ANDROGEN RECEPTOR; HUMAN SPERMATOZOA; LONGER TELOMERES; GRANULOSA-CELLS; STRAND BREAKS; MOUSE OOCYTES;

D O I：

10.3390/ijms25168652

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The number of infertile couples undergoing in vitro fertilisation (IVF) has increased significantly. The efficacy of this procedure is contingent upon a multitude of factors, including gamete quality. One factor influencing gamete quality is oxidative stress, which leads to telomere damage and accelerates cellular ageing. Identifying new biomarkers that can predict the success of assisted reproduction techniques is a current relevant area of research. In this review, we discuss the potential role of SIRT1, a protein known to protect against oxidative stress and telomeres, which are responsible for genome stability, as biomarkers of gamete quality and assisted reproduction technique outcomes.

引用

页数：19

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