Incidence of Myocardial Injury and Cardiac Dysfunction After Adult Traumatic Brain Injury: A Systematic Review and Meta-analysis

被引：2

作者：

Chaikittisilpa, Nophanan ^{[1
,2
]}

Kiatchai, Taniga ^{[1
,2
]}

Liu, Sunny Yang ^{[3
,4
]}

Kelly-Hedrick, Margot ^{[3
,4
]}

Vavilala, Monica S. ^{[2
,5
]}

Lele, Abhijit V. ^{[2
,5
]}

Komisarow, Jordan ^{[3
,6
]}

Ohnuma, Tetsu ^{[3
,7
]}

Colton, Katharine ^{[8
]}

Krishnamoorthy, Vijay ^{[2
,3
,7
]}

机构：

[1] Mahidol Univ, Siriraj Hosp, Dept Anesthesiol, Bangkok, Thailand

[2] Univ Washington, Harborview Injury Prevent Res Ctr, Seattle, WA USA

[3] Duke Univ, Dept Anesthesiol, Crit Care & Perioperat Populat Hlth Res CAPER Unit, Durham, NC USA

[4] Duke Univ, Sch Med, Durham, NC USA

[5] Univ Washington, Dept Anesthesiol & Pain Med, Seattle, WA USA

[6] Duke Univ, Dept Neurosurg, Durham, NC USA

[7] Duke Univ, Dept Anesthesiol, Durham, NC 27708 USA

[8] Duke Univ, Dept Emergency Med, Durham, NC USA

来源：

JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY | 2024年 / 36卷 / 04期

关键词：

traumatic brain injury; cardiac dysfunction; troponin; echocardiography; systematic review; TROPONIN-I; ASSOCIATION; HEMORRHAGE; GUIDELINES; MANAGEMENT; BIOMARKER; GUIDANCE; DISEASE;

D O I：

10.1097/ANA.0000000000000945

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Myocardial injury and cardiac dysfunction after traumatic brain injury (TBI) have been reported in observational studies, but there is no robust estimate of their incidences. We conducted a systematic review and meta-analysis to estimate the pooled incidence of myocardial injury and cardiac dysfunction among adult patients with TBI. A literature search was conducted using MEDLINE and EMBASE databases from inception to November 2022. Observational studies were included if they reported at least one abnormal electrocardiographic finding, elevated cardiac troponin level, or echocardiographic evaluation of systolic function or left ventricular wall motion in adult patients with TBI. Myocardial injury was defined as elevated cardiac troponin level according to the original studies and cardiac dysfunction was defined as the presence of left ventricular ejection fraction <50% or regional wall motion abnormalities assessed by echocardiography. The meta-analysis of the pooled incidence of myocardial injury and cardiac dysfunction was performed using random-effect models. The pooled estimated incidence of myocardial injury after TBI (17 studies, 3,773 participants) was 33% (95% CI: 27%-39%, I 2:s 93%), and the pooled estimated incidence of cardiac dysfunction after TBI (9 studies, 557 participants) was 16.% (95% CI: 9%-25.%, I 2: 84%). Although there was significant heterogeneity between studies and potential overestimation of the incidence of myocardial injury and cardiac dysfunction, our findings suggest that myocardial injury occurs in approximately one-third of adults after TBI, and cardiac dysfunction occurs in approximately one-sixth of patients with TBI.

引用

页码：283 / 293

页数：11