Extracellular vesicles in fetal-maternal immune tolerance

被引：7
作者：
Burlingham, William J. [1 ]
机构：
[1] Univ Wisconsin, 600 Highland Ave, Madison, WI 53792 USA
来源：
BIOMEDICAL JOURNAL | 2024年 / 47卷 / 05期
关键词：
Immunology; Tolerance; Exosomes; Pregnancy; REGULATORY T-CELLS; TRANSPLANTATION; CONTRIBUTES; ANTIGENS; RECEPTOR; PROMOTE; SURFACE;
D O I：
10.1016/j.bj.2024.100785
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Two key problems of allo-tolerance during fetal-maternal co-existence are: 1) it's focus must be local, allowing the mother's continued peripheral immune competence to resist pathogens ubiquitously, and 2) it must propagate itself, i.e. continuously recruit new re-enforcements of the local tolerant state. Both are solved by the exosomal pathway of Tregs & Bregs. While the fetal-maternal accomodations of pregnancy terminate at the time of partrurition, geography, climate and the endemic pathogens of the environment surrounding the mother-baby pair would then define the short and long-term effects of their immunologic interaction.
引用
收藏
页数：4
相关论文
共 24 条
[1]   ACTIVELY ACQUIRED TOLERANCE OF FOREIGN CELLS [J].
BILLINGHAM, RE ;
BRENT, L ;
MEDAWAR, PB .
NATURE, 1953, 172 (4379) :603-606
[2]   Modification of host dendritic cells by microchimerism-derived extracellular vesicles generates split tolerance [J].
Bracamonte-Baran, William ;
Florentin, Jonathan ;
Zhou, Ying ;
Jankowska-Gan, Ewa ;
Haynes, W. John ;
Zhong, Weixiong ;
Brennan, Todd V. ;
Dutta, Partha ;
Claas, Frans H. J. ;
van Rood, Jon J. ;
Burlingham, William J. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (05) :1099-1104
[3]   Extracellular Vesicle-associated GARP/TGFβ:LAP Mediates "Infectious" Allo-tolerance [J].
Burlingham, William J. ;
Jankowska-Gan, Ewa ;
Fechner, John H. ;
Little, Christopher J. ;
Wang, Jianxin ;
Hong, Seungpyo ;
Molla, Miraf ;
Sullivan, Jeremy A. ;
Foley, David P. .
TRANSPLANTATION DIRECT, 2023, 9 (06)
[4]   The effect of tolerance to noninherited maternal HLA antigens on the survival of renal transplants from sibling donors [J].
Burlingham, WJ ;
Grailer, AP ;
Heisey, DM ;
Claas, FHJ ;
Norman, D ;
Mohanakumar, T ;
Brennan, DC ;
De Fijter, H ;
Van Gelder, T ;
Pirsch, JD ;
Sollinger, HW ;
Bean, MA .
NEW ENGLAND JOURNAL OF MEDICINE, 1998, 339 (23) :1657-1664
[5]   Interleukin-35: odd one out or part of the family? [J].
Collison, Lauren W. ;
Vignali, Dario A. A. .
IMMUNOLOGICAL REVIEWS, 2008, 226 :248-262
[6]   The inhibitory cytokine IL-35 contributes to regulatory T-cell function [J].
Collison, Lauren W. ;
Workman, Creg J. ;
Kuo, Timothy T. ;
Boyd, Kelli ;
Wang, Yao ;
Vignali, Kate M. ;
Cross, Richard ;
Sehy, David ;
Blumberg, Richard S. ;
Vignali, Dario A. A. .
NATURE, 2007, 450 (7169) :566-U19
[7]   The composition and signaling of the IL-35 receptor are unconventional [J].
Collison, Lauren W. ;
Delgoffe, Greg M. ;
Guy, Clifford S. ;
Vignali, Kate M. ;
Chaturvedi, Vandana ;
Fairweather, DeLisa ;
Satoskar, Abhay R. ;
Garcia, K. Christopher ;
Hunter, Christopher A. ;
Drake, Charles G. ;
Murray, Peter J. ;
Vignali, Dario A. A. .
NATURE IMMUNOLOGY, 2012, 13 (03) :290-U115
[8]   IL-35-mediated induction of a potent regulatory T cell population [J].
Collison, Lauren W. ;
Chaturvedi, Vandana ;
Henderson, Abigail L. ;
Giacomin, Paul R. ;
Guy, Cliff ;
Bankoti, Jaishree ;
Finkelstein, David ;
Forbes, Karen ;
Workman, Creg J. ;
Brown, Scott A. ;
Rehg, Jerold E. ;
Jones, Michael L. ;
Ni, Hsiao-Tzu ;
Artis, David ;
Turk, Mary Jo ;
Vignali, Dario A. A. .
NATURE IMMUNOLOGY, 2010, 11 (12) :1093-U97
[9]   Decidual natural killer cells: key regulators of placental development (a review) [J].
Croy, BA ;
Chantakru, S ;
Esadeg, S ;
Ashkar, AA ;
Wei, QX .
JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2002, 57 (1-2) :151-168
[10]   Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin [J].
Devergne, O ;
Birkenbach, M ;
Kieff, E .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (22) :12041-12046
123